Document Detail

Impaired social cognition in mild Alzheimer disease.
MedLine Citation:
PMID:  19321881     Owner:  NLM     Status:  MEDLINE    
Abnormal decoding of social information has been associated with the conversion from prodromal Alzheimer's disease (AD) to dementia. Since the distributed neural networks involved in face processing are differentially affected in prodromal and dementia states of AD and in Fronto-Temporal Dementia (FTD), we hypothesized a differential impairment in face processing in these populations. Facial expression, gender and gaze direction decoding abilities were examined in patients with probable amnesic Mild Cognitive Impairment (aMCI, N=10) fulfilling criteria for prodromal AD, in patients with mild and moderate AD (N=10) as well as in FTD patients (N=10) and in a group of age- and sex-matched healthy comparison subjects (N=10). Gender recognition was preserved in all groups. Compared to controls, patients with mild or moderate AD were impaired in expression recognition and FTD patients were impaired in expression and gaze direction determination, whereas MCI patients were not impaired at all.
Benoit Bediou; Ilham Ryff; Bernadette Mercier; Maud Milliery; Marie-Anne Hénaff; Thierry D'Amato; Marc Bonnefoy; Alain Vighetto; Pierre Krolak-Salmon
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-03-25
Journal Detail:
Title:  Journal of geriatric psychiatry and neurology     Volume:  22     ISSN:  0891-9887     ISO Abbreviation:  J Geriatr Psychiatry Neurol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-06     Completed Date:  2009-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8805645     Medline TA:  J Geriatr Psychiatry Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  130-40     Citation Subset:  IM    
Université de Lyon, Service de Neurologie, Centre Hospitalier Lyon Sud, Lyon, F-69003, France.
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MeSH Terms
Alzheimer Disease / diagnosis*,  psychology
Amnesia / diagnosis,  psychology
Cognition Disorders / diagnosis*,  psychology
Dementia / diagnosis,  psychology
Diagnosis, Differential
Face / anatomy & histology
Facial Expression*
Fixation, Ocular
Neuropsychological Tests
Recognition (Psychology)
Severity of Illness Index
Sex Characteristics
Social Perception*
Visual Perception*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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