Document Detail

Impaired sensitivity of a single early leukocyte count in screening for neonatal sepsis.
MedLine Citation:
PMID:  3601489     Owner:  NLM     Status:  MEDLINE    
The common clinical practice of using a single, early white blood cell (WBC) count to screen for early onset neonatal sepsis was investigated in a population of 61 newborn infants with culture proven sepsis in the first 3 days of life. Thirteen patients (21%) had a falsely normal WBC screening test. The patients with true positive and falsely normal WBC counts did not differ by risk factors for sepsis, birth weight, age, outcome or severity of disease. However, there was a significant delay between the screening test and the positive blood culture in the patients with false normal WBC counts and not in the patients with positive abnormal WBC counts (14.9 +/- 5.9 hours vs. 2.8 +/- 1.4 hr, mean +/- SE, P less than 0.001). A WBC count obtained soon after birth as currently utilized may not adequately screen for early onset neonatal sepsis.
H J Rozycki; G E Stahl; S Baumgart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  6     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-07-31     Completed Date:  1987-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  440-2     Citation Subset:  IM    
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MeSH Terms
False Negative Reactions
Infant, Newborn
Leukocyte Count*
Predictive Value of Tests
Sepsis / blood,  diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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