| Impaired response to exercise intervention in the vasculature in metabolic syndrome. | |
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MedLine Citation:
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PMID: 23162060 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Physical activity decreases risk for diabetes and cardiovascular disease morbidity and mortality; however, the specific impact of exercise on the diabetic vasculature is unexamined. We hypothesized that an acute, moderate exercise intervention in diabetic and hypertensive rats would induce mitochondrial biogenesis and mitochondrial antioxidant defence to improve vascular resilience. SHHF/Mcc-fa(cp) lean (hypertensive) and obese (hypertensive, insulin resistant), as well as Sprague Dawley (SD) control rats were run on a treadmill for 8 days. In aortic lysates from SD rats, we observed a significant increase in subunit proteins from oxidative phosphorylation (OxPhos) complexes I-III, with no changes in the lean or obese SHHF rats. Exercise also increased the expression of mitochondrial antioxidant defence uncoupling protein 3 (UCP3) (p < 0.05) in SHHF lean rats, whereas no changes were observed in the SD or SHHF obese rats with exercise. We evaluated upstream signalling pathways for mitochondrial biogenesis, and only peroxisome proliferators-activated receptor gamma coactivator 1α (PGC-1α) significantly decreased in SHHF lean rats (p < 0.05) with exercise. In these experiments, we demonstrate absent mitochondrial induction with exercise exposure in models of chronic vascular disease. These findings suggest that chronic vascular stress results in decreased sensitivity of vasculature to the adaptive mitochondrial responses normally induced by exercise. |
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Authors:
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Leslie A Knaub; Sylvia McCune; Adam J Chicco; Matthew Miller; Russell L Moore; Nicholas Birdsey; Monique I Lloyd; Juan Villarreal; Amy C Keller; Peter A Watson; Jane Eb Reusch |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-16 |
Journal Detail:
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Title: Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease Volume: - ISSN: 1752-8984 ISO Abbreviation: Diab Vasc Dis Res Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234011 Medline TA: Diab Vasc Dis Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Diabetes and Metabolism, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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