Document Detail

Impaired renal water excretion in early hepatic cirrhosis. Lack of relationship between renal water excretion and plasma levels of arginine vasopressin, angiotensin II, and aldosterone after water loading.
MedLine Citation:
PMID:  3749808     Owner:  NLM     Status:  MEDLINE    
An oral water load of 20 ml per kg body weight was given to 9 patients with hepatic cirrhosis and 11 healthy controls. Urinary output, free water clearance, and plasma concentrations of arginine vasopressin, angiotensin II and aldosterone were determined before and three times during the first 4 h after loading. In the cirrhotic patients urinary output was significantly lower after loading than in the control subjects, mainly because of a lower free water clearance, and, in contrast to the healthy controls, the cirrhotic patients did not have natriuresis after water loading. No differences were found between patients and controls in arginine vasopressin, angiotensin II, aldosterone, or creatinine clearance. It is concluded that patients with well-compensated cirrhosis of the liver have an impaired ability to excrete sodium and water. This phenomenon does not seem to be due to increased arginine vasopressin secretion, activation of the renin-angiotensin-aldosterone system, or a decreased glomerular filtration rate.
M Madsen; E B Pedersen; H Danielsen; L S Jensen; S S Sørensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  21     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-10-15     Completed Date:  1986-10-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  749-55     Citation Subset:  IM    
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MeSH Terms
Aldosterone / blood*
Angiotensin II / blood*
Arginine Vasopressin / blood*
Body Water / metabolism*
Creatinine / metabolism
Kidney / physiopathology*
Liver Cirrhosis, Alcoholic / physiopathology*
Middle Aged
Reg. No./Substance:
11128-99-7/Angiotensin II; 113-79-1/Arginine Vasopressin; 52-39-1/Aldosterone; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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