| Impaired renal prostaglandin E2 biosynthesis in human hypertensive states. | |
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MedLine Citation:
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PMID: 213795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urinary Prostaglandin E2 (PGE2), a known indicator of renal production, was measured by specific radioimmunoassay in 111 normal volunteers, 85 patients with essential hypertension, 6 with renovascular hypertension, and 23 patients with primary aldosteronism. Women excreted less PGE2 than men in both normotensive and hypertensive groups. When compared to normals, essential hypertensives demonstrated significantly lower PGE2 levels, with one third excreting less than 100 ng/24 hr, values usually seen only in subjects receiving the prostaglandin synthetase inhibitor, indomethacin. Normal PGE2 was seen in patients with renovascular hypertension, and levels were uninfluenced by treatment with the converting enzyme inhibitor SQ14225, Despite normalization of blood pressure and increased plasma renin activity. Normal PGE2 was also encountered in primary aldosteronism. These data indicate that impaired renal PGE2 biosynthesis is specific for human essential hypertension, and is not secondary to the elevated blood pressure. Although PGE2 excretion tends to be lower in low-renin hypertension, a constant relationship between PGE2 and renin is not always apparent. |
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Authors:
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S Y Tan; E Bravo; P J Mulrow |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Prostaglandins and medicine Volume: 1 ISSN: 0161-4630 ISO Abbreviation: Prostaglandins Med Publication Date: 1978 Jul |
Date Detail:
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Created Date: 1979-01-26 Completed Date: 1979-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7810330 Medline TA: Prostaglandins Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 76-85 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors Female Humans Hyperaldosteronism / metabolism Hypertension / enzymology, metabolism* Hypertension, Renovascular / metabolism Indomethacin / pharmacology Kidney / metabolism* Male Middle Aged Prostaglandins E / biosynthesis*, urine Renin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Prostaglandins E; 53-86-1/Indomethacin; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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