Document Detail

Impaired pulmonary oxygenation of diabetic origin in patients undergoing coronary artery bypass grafting.
MedLine Citation:
PMID:  8076003     Owner:  NLM     Status:  MEDLINE    
The effect of a disposition to diabetes mellitus on pulmonary function was determined by dividing 70 consecutive patients who underwent coronary artery bypass grafting (CABG) into a group of 41 patients with such a disposition and a group of 29 without. Indices of pulmonary function studied were the ratio of the arterial partial pressure of oxygen to the inspired oxygen fraction (PaO2/FiO2), the alveolar-arterial oxygen gradient (A-aDO2) and the respiratory index (A-aDO2/PaO2). These were determined before CABG, at the maximum level of blood glucose and when FiO2 was in the range 0.4-0.7 within 6 h after CABG. Even before bypass, all indices were significantly worse in the group with a disposition to diabetes mellitus than in that without. After surgery, these dysfunctions were more severely exacerbated in the former group. FiO2 was the best predictor of the current state of pulmonary function in both groups. Variables that strongly affected pulmonary function were pulmonary arterial wedge pressure in the group with no diabetic disposition and central venous pressure in those with such a disposition. Thus, pulmonary dysfunction of diabetic origin exists not only before CABG, but also after the procedure. Attending physicians must be careful not to increase wedge pressure and central venous pressure.
S Seki; H Yoshida; Y Momoki; O Ooba; S Teramoto; Y Komoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  1     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1994-10-06     Completed Date:  1994-10-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  72-8     Citation Subset:  IM    
Department of Acute Medicine, Okayama University School of Medicine, Japan.
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MeSH Terms
Blood Glucose / metabolism
Coronary Artery Bypass*
Coronary Disease / physiopathology,  surgery*
Diabetes Complications*
Diabetes Mellitus / physiopathology
Diabetic Angiopathies / physiopathology*
Hemodynamics / physiology
Lung / blood supply*
Middle Aged
Oxygen / blood*
Postoperative Complications / physiopathology*
Regional Blood Flow / physiology
Respiratory Function Tests
Risk Factors
Reg. No./Substance:
0/Blood Glucose; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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