Document Detail

Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer.
MedLine Citation:
PMID:  3807974     Owner:  NLM     Status:  MEDLINE    
The defensive factors that prevent the human duodenal mucosa from acidic and peptic damage have not been fully evaluated. To determine whether duodenal mucosal bicarbonate production was altered in patients with inactive duodenal ulcer, we measured basal and acid-stimulated bicarbonate output from the duodenal bulb and the distal duodenum in healthy subjects and patients with inactive duodenal ulcer. As compared with 16 normal subjects, the 12 patients had significantly less mean (+/- SE) basal proximal duodenal mucosal bicarbonate secretion (185 +/- 13 vs. 107 +/- 18 mumol per centimeter per hour; P less than 0.001). Moreover, in response to a physiologic amount of hydrochloric acid (2 mmol per five minutes) instilled directly into the duodenal bulb, peak proximal duodenal bicarbonate output in the patients was 41 percent of the normal response (263 +/- 65 vs. 642 +/- 77 mumol per centimeter per hour; P less than 0.01). There was little overlap between groups. In contrast, bicarbonate outputs in the distal duodenum were similar in the two groups. We conclude that most patients with duodenal ulcer disease have decreased proximal duodenal mucosal bicarbonate production at rest, in response to hydrochloric acid, and in relation to peak gastric acid secretion. Impaired proximal duodenal mucosal bicarbonate secretion may be an important factor in the development and natural history of duodenal ulcer.
J I Isenberg; J A Selling; D L Hogan; M A Koss
Related Documents :
7673614 - The potential value of lansoprazole in helicobacter pylori eradication.
18076214 - Proton pump inhibitors: do differences in pharmacokinetics translate into differences i...
9251824 - Helicobacter pylori survival in gastric mucosa by generation of a ph gradient.
2877324 - Effect of duodenal ulcer surgery and enterogastric reflux on campylobacter pyloridis.
10964674 - Loss of cell viability by histidine substitution of leucine 325 of the glutamate transp...
3086174 - Pharmacologic evaluation of various metabolites and analogs of valproic acid: teratogen...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  316     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-06     Completed Date:  1987-03-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  374-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bicarbonates / secretion*
Duodenal Ulcer / physiopathology*
Duodenum / secretion*
Hydrochloric Acid / diagnostic use
Intestinal Mucosa / secretion
Middle Aged
Grant Support
Reg. No./Substance:
0/Bicarbonates; 7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Epidemiology as a liberal art.
Next Document:  Comparisons of national cesarean-section rates.