Document Detail

Impaired pressure natriuresis is associated with interstitial inflammation in salt-sensitive hypertension.
MedLine Citation:
PMID:  23165109     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Impairment of the pressure natriuresis relationship is a central event in the pathogenesis of hypertension. Renal tubulointerstitial inflammation results in salt-sensitive hypertension and, until recently, the changes in pressure natriuresis induced by renal inflammation received little attention.
RECENT FINDINGS: Oxidative stress and increased intrarenal angiotensin II activity, in association with rarefaction and loss of peritubular vascular network, may be involved in the inflammation-induced blunting of the natriuresis resulting from increments in renal perfusion pressure.
SUMMARY: Here, we review the mechanisms for the impairment in pressure natriuresis resulting from renal tubulointerstitial inflammation in reference to the normal physiologic mechanisms involved in this response.
Bernardo Rodriguez-Iturbe; Martha Franco; Richard J Johnson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  22     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-06-03     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  37-44     Citation Subset:  IM    
The Renal Service, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela.
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MeSH Terms
Angiotensin II / metabolism
Hypertension / physiopathology*
Kidney Tubules / blood supply
Microvessels / physiopathology
Natriuresis / physiology*
Nephritis, Interstitial / metabolism,  physiopathology*
Oxidative Stress
Sodium Chloride, Dietary / adverse effects
Grant Support
Reg. No./Substance:
0/Sodium Chloride, Dietary; 11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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