| Impaired pancreatic endocrine and exocrine responses in growth-retarded piglets. | |
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MedLine Citation:
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PMID: 15109236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The alteration of pancreatic endocrine and exocrine secretory responses induced by secretagogues and neural input was investigated in post-weaning growth-retarded (GR) piglets. Blood and pancreatic juice were collected from these animals (6-8-weeks old). Plasma insulin and pancreatic digestive enzymes induced by nutrients, drugs and vagal stimulation were measured biochemically. The pancreas was inspected by immunohistochemical analysis. In GR piglets, the plasma glucose and insulin concentrations at the resting state were very low, and the secretory response was also markedly reduced, with maximum inhibition of 90% by glucose administration and 83% by arginine administration. The insulin secretion was not increased by 2-deoxy-D-glucose administration in GR piglets. The pancreatic juice secretions induced by vagal stimulation and secretagogues in GR piglets were not different from those induced in the control piglets. However, amylase activity in the pancreatic juice and in the pancreas was significantly decreased in GR piglets, although trypsin and chymotrypsin activities were not different. In the immunohistochemical analysis, the numbers of islets and the staining degree for insulin antibody also declined in the pancreases of GR piglets. These results indicated the reduction of insulin and amylase secretions from the pancreas in GR piglets, suggesting that a dysfunction of pancreatic endocrine and exocrine secretion during growth after weaning may be an important factor in the induction of growth retardation in piglets. |
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Authors:
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E Harada; M Shizuyama; N Ihara; T Takeuchi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine Volume: 50 ISSN: 0931-184X ISO Abbreviation: J Vet Med A Physiol Pathol Clin Med Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2004-04-27 Completed Date: 2004-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100955112 Medline TA: J Vet Med A Physiol Pathol Clin Med Country: Germany |
Other Details:
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Languages: eng Pagination: 433-41 Citation Subset: IM |
Affiliation:
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Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Tottori, Japan. harada@muses.tottori-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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metabolism Animals Arginine / metabolism, pharmacology Blood Glucose / metabolism* Caerulein / pharmacology Case-Control Studies Catecholamines / metabolism, pharmacology Electric Stimulation Glucose / pharmacology Growth Disorders / physiopathology, veterinary* Immunohistochemistry / veterinary Insulin / blood, secretion* Islets of Langerhans / secretion* Pancreas / enzymology, growth & development, secretion* Pancreatic Juice / secretion Swine Swine Diseases / physiopathology* Vagus Nerve / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Catecholamines; 11061-68-0/Insulin; 17650-98-5/Caerulein; 50-99-7/Glucose; 74-79-3/Arginine; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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