| Impaired oxidative metabolism in exercising muscle from ALS patients. | |
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MedLine Citation:
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PMID: 11676993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathogenic mechanism of selective loss of motor neurones in amyotrophic lateral sclerosis (ALS) is still poorly understood. Recently, research evidence has suggested that mitochondrial dysfunction occurs in central nervous system as well as in peripheral tissues from ALS patients. The aim of our study was to indirectly investigate in vivo oxidative metabolism of exercising muscle in a case history of patients affected by ALS. To this purpose 11 patients, 8 male and 3 female, mean age+/-SD: 52.4+/-11.1 years, performed a bicycle incremental test for the assessment of lactate production. At rest, there was increased lactate concentration in patients: 2.77+/-0.79 vs. 1.48+/-0.49 mmol/l in normal controls (normal range: 0.67-2.47 mmol/l). Analysis of lactate curve during exercise showed a lactate production increase compared to controls. Furthermore, anaerobic lactate threshold was detected at 40-50% of the predicted normal power output, anticipated with respect to both normal subjects and non-ALS chronically denervated controls with comparable motor impairment (60-70%), suggesting that mitochondrial dysfunction can occur in exercising skeletal muscle from ALS patients. |
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Authors:
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G Siciliano; E Pastorini; L Pasquali; M L Manca; A Iudice; L Murri |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 191 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-25 Completed Date: 2002-01-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 61-5 Citation Subset: IM |
Affiliation:
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Neurological Clinics, Department of Neuroscience, University of Pisa, Via Roma 67, 56126, Pisa, Italy. gsicilia@med.unipi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amyotrophic Lateral Sclerosis / physiopathology* Electromyography Exercise Test Female Heart Rate Humans Lactic Acid / blood Male Middle Aged Mitochondria / metabolism Muscle, Skeletal / physiopathology* Neuromuscular Diseases / physiopathology Oxidation-Reduction Oximetry Oxygen Consumption Physical Exertion* Reference Values |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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