| Impaired orthograde axonal transport in acute hypoglycaemia, an effect mediated via hypothermia. | |
| | |
MedLine Citation:
|
PMID: 6205228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of hypoglycaemia (blood glucose 1 mmol/l) on the axonal transport of acetylcholinesterase activity and noradrenaline was examined in non-diabetic rats. Rats were made hypoglycaemic over a 6-h period during which acetylcholinesterase and noradrenaline accumulated proximal to a tight ligature applied to the left sciatic nerve. The hypoglycaemic rats were either kept at room temperature, when they became profoundly hypothermic, or kept in a 31 degrees C incubator to maintain body temperature as close to normal as possible. Hypoglycaemia without temperature control caused marked reductions in the accumulation of acetylcholinesterase activity and of noradrenaline proximal to the ligature. These accumulation deficits were obviated by body heating. The findings indicate that hypoglycaemia impairs fast orthograde axonal transport, but that this effect is a consequence of hypothermia rather than glucopenia. |
| | |
Authors:
|
D R Tomlinson; P J James |
Related Documents
:
|
7225948 - Evidence of environmental influence on the development of thermoregulation in the rat. 4698498 - The influence of body temperature on the ventilatory response to co 2 in anaesthetized... 623208 - X-ray microprobe analysis of michaelis-gutmann bodies in human and experimental malakop... 16187838 - Separable brainstem and forebrain contributions to ultrasonic vocalizations in infant r... 8840478 - A model for acute carbon monoxide poisoning in conscious rats. 17662668 - Effects of l-name on thromboxane a2-induced venoconstriction in isolated perfused liver... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Medical biology Volume: 62 ISSN: 0302-2137 ISO Abbreviation: Med. Biol. Publication Date: 1984 |
Date Detail:
|
Created Date: 1984-08-27 Completed Date: 1984-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0417300 Medline TA: Med Biol Country: FINLAND |
Other Details:
|
Languages: eng Pagination: 34-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholinesterase
/
metabolism Animals Axonal Transport* Hypoglycemia / physiopathology* Hypothermia / physiopathology* Male Norepinephrine / metabolism Rats Rats, Inbred Strains Sciatic Nerve / physiopathology |
| Chemical | |
Reg. No./Substance:
|
51-41-2/Norepinephrine; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of fixation and staining techniques on the ultrastructure of the insulin secretory granule...
Next Document: Chronic granulocytic leukemia.