| Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X. | |
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MedLine Citation:
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PMID: 12098655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 08:00 h. Melatonin levels were measured with a radioimmunoassay kit. Patients with cardiac syndrome X secreted less nocturnal melatonin at 02:00 h than control subjects (P=0.04). Peak and Delta melatonin (peak-lowest melatonin) were found lower in patients with cardiac syndrome X (P=0.039 and P=0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients. |
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Authors:
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Armagan Altun; Mevlut Yaprak; Meryem Aktoz; Arzu Vardar; Ugur Altun Betul; Gultac Ozbay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 327 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-05 Completed Date: 2002-09-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 143-5 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Medical School, Trakya University, Edirne, Turkey. altun@medscape.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Circadian Rhythm Female Humans Male Melatonin / biosynthesis*, blood Microvascular Angina / metabolism* Middle Aged Pineal Gland / metabolism Sympathetic Nervous System / physiology Vagus Nerve / physiology |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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