| Impaired neostigmine antagonism of pancuronium during enflurane anaesthesia in man. | |
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MedLine Citation:
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PMID: 7066141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have compared the rates of recovery of pancuronium-induced neuromuscular blockade after administration of neostigmine during anaesthesia maintained with nitrous oxide and intermittent narcotics, halothane or enflurane. Thirty patients were studied in whom anaesthesia was maintained with 70% nitrous oxide in oxygen with: fentanyl or thiopentone, halothane (0.55-0.65% end-tidal), or enflurane (1.3-1.4% end-tidal). Muscle twitch response was measured using train-of-four stimulation. Pancuronium 3 mg/70 kg was antagonized with neostigmine 2.5 mg/70 kg at 10% spontaneous recovery of the first twitch of the train compared with control. There were no significant differences between the times to 10% spontaneous recovery of the first twitch or the rates of train-of-four recovery after neostigmine when the narcotic and halothane groups were compared. However, enflurane anaesthesia, in comparison with fentanyl, was associated with a significant increase in the time to 10% recovery (57.9 +/- 6.0 min v. 35.4 +/- 7.0 min) and with decreases in the train-of-four recoveries at 4, 5, 10, 20 and 30 min after neostigmine. We conclude that, under the conditions of this study, the antagonism of pancuronium-induced neuromuscular blockade with neostigmine was impaired during enflurane but not halothane anaesthesia. |
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Authors:
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S Delisle; D R Bevan |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of anaesthesia Volume: 54 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1982 Apr |
Date Detail:
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Created Date: 1982-06-24 Completed Date: 1982-06-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 441-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anesthesia, Inhalation* Drug Interactions Enflurane / pharmacology* Halothane / pharmacology Humans Middle Aged Muscle Contraction / drug effects Neostigmine / pharmacology* Pancuronium / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Pancuronium; 13838-16-9/Enflurane; 151-67-7/Halothane; 59-99-4/Neostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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