Document Detail

Impaired natural killer activity in lymphohistiocytosis syndrome.
MedLine Citation:
PMID:  6368780     Owner:  NLM     Status:  MEDLINE    
In six patients with well-documented lymphohistiocytosis syndrome, natural killer activity was found to be profoundly impaired and could not be increased by incubation in vitro with interferon. This abnormality was not found in parents of the affected children. A clear correlation with the activity of the disease was observed, although a delay of a few weeks (possibly reflecting the life span of NK cells in blood) was seen in the disappearance of NK activity after the onset of the disease and its reappearance after remission. No absolute correlation was observed between NK activity and percentage of leukocytes detected by the Leu-7 monoclonal antibody. Our findings indicate that testing NK activity is useful for the diagnosis of lymphohistiocytosis syndrome and can be used as an index of activity of the disease, among other major clinical and biologic signs of this syndrome. Reversal of the NK activity defect (rather than detection of Leu-7 positive cells) appears to be a good criterion of complete remission.
N Perez; J L Virelizier; F Arenzana-Seisdedos; A Fischer; C Griscelli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  104     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-15     Completed Date:  1984-05-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  569-73     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Monoclonal / immunology
Cytotoxicity, Immunologic
Fluorescent Antibody Technique
Killer Cells, Natural / immunology*
Leukocytes / immunology
Lymphatic Diseases / diagnosis,  immunology*
Reg. No./Substance:
0/Antibodies, Monoclonal

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