Document Detail

Impaired myocardial oxidative metabolism in the remote normal region in patients in the chronic phase of myocardial infarction and left ventricular remodeling.
MedLine Citation:
PMID:  19152131     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Left ventricular (LV) remodeling occurs in the remote normal region in the LVs after myocardial infarction (MI) and is closely involved in heart failure. METHODS: We assessed myocardial oxygen consumption using a clearance rate constant K (mono) for the time activity curves of (11)C-acetate in 15 patients with a prior anterior wall MI, 8 with a prior inferior wall MI, and 10 age-matched normal control subjects. LV end-systolic volume index (ESVI) was determined by echocardiography. RESULTS: The LVESVI was significantly greater in patients with an anterior and inferior MI than in control subjects. The heart rate systolic pressure product did not differ among the groups. K (mono) in the remote normal region in patients with an anterior MI was significantly less than that in the corresponding area in control subjects (0.055 +/- 0.005 vs 0.065 +/- 0.008 min(-1), P < .001). K (mono) in the remote normal region in those with an inferior MI was also significantly less compared with controls (0.054 +/- 0.007 vs 0.069 +/- 0.010 min(-1), P < .01). CONCLUSION: In patients with a prior MI and LV remodeling, myocardial oxidative metabolism is apparently impaired in the remote normal region where augmented myocardial energy production is needed against the increased end-systolic wall stress caused by LV dilatation.
Nobuyuki Ohte; Hitomi Narita; Akihiko Iida; Kazuaki Wakami; Kaoru Asada; Hidekatsu Fukuta; Takafumi Kato; Junichiro Hyano; Genjiro Kimura
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-20
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  16     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-81     Citation Subset:  IM    
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
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MeSH Terms
Chronic Disease
Metabolic Clearance Rate
Myocardial Infarction / metabolism*
Oxygen / metabolism*
Oxygen Consumption*
Ventricular Dysfunction, Left / metabolism*
Ventricular Remodeling*
Reg. No./Substance:

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