Document Detail


Impaired myocardial lipid metabolism in phosphate depletion.
MedLine Citation:
PMID:  6482177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examines the effects of phosphate depletion on myocardial carbohydrate, lipid, and phospholipid metabolism. Rats were studied after 4 (short-term) and 8 to 12 weeks (long-term) of selective dietary phosphate restriction. Myocardial biopsy samples were examined for glucose-6-phosphate and glycogen to evaluate carbohydrate pathways, and for glycerol phosphate and mitochondrial fatty acid oxidation and phospholipid contents to evaluate lipid and phospholipid turnover. The fall in cellular inorganic phosphorus was associated with a fall in myocardial glycogen, glucose-6-phosphate, glycerol phosphate, and cytidine triphosphate, as well as the contents of phosphatidylcholine, phosphatidylethanolamine, and total phospholipid phosphorus. These observations demonstrate impaired phospholipid metabolism, probably at the biosynthetic level. The oxidation of long-chain and short-chain fatty acids is also impaired in phosphate depletion, further demonstrating impaired lipid metabolism. The abnormal phospholipid metabolism may be compatible with the changes in cellular membrane described in phosphate depletion.
Authors:
N Brautbar; J Tabernero-Romo; J C Coats; S G Massry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Kidney international     Volume:  26     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-11-19     Completed Date:  1984-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbohydrate Metabolism
Cytidine Triphosphate / metabolism
Fatty Acids / metabolism
Glucose-6-Phosphate
Glucosephosphates / metabolism
Glycerophosphates / metabolism
Glycogen / metabolism
Lipid Metabolism*
Myocardium / metabolism*
Oxidation-Reduction
Phosphates / deficiency*
Phosphatidylcholines / metabolism
Phosphatidylethanolamines / metabolism
Phospholipids / biosynthesis,  metabolism
Phosphorus / blood,  metabolism
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
AM29955/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Glucosephosphates; 0/Glycerophosphates; 0/Phosphates; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids; 56-73-5/Glucose-6-Phosphate; 57-03-4/alpha-glycerophosphoric acid; 65-47-4/Cytidine Triphosphate; 7723-14-0/Phosphorus; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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