| Impaired myocardial blood flow reserve in subjects with metabolic syndrome analyzed using positron emission tomography and N-13 labeled ammonia. | |
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MedLine Citation:
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PMID: 19915835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Coronary vasomotor response might be impaired in metabolic syndrome (MS); however, the precise abnormality has not been elucidated. The aim of this study was to assess coronary-vasomotor response in MS subjects using N-13 labeled ammonia and positron emission tomography. METHODS AND RESULTS: Myocardial blood flow (MBF) was measured at rest and during adenosine infusion in MS subjects (n = 13, MS group) with no definite evidence of heart disease and in subjects without MS (n = 14, non-MS group). Coronary vascular resistance (CVR) was calculated by dividing the mean aortic blood pressure by MBF. Myocardial blood flow reserve (MFR) was calculated as the ratio of the MBF during adenosine infusion to that during rest. Blood chemical parameters were measured to evaluate their relationship with MFR. During adenosine infusion, MBF was lower (p = 0.0085) and CVR higher (p = 0.0128) in the MS group than in the non-MS group and MFR was significantly lower in the MS group than in the non-MS group (2.13 +/- 0.99 vs. 3.38 +/- 0.95, p = 0.0027). Multivariate analysis demonstrated that the homeostasis model assessment-insulin resistance (p < 0.05) and the presence of hypertension (p < 0.05) were independent determinants of MFR. CONCLUSIONS: The results indicate that MFR was impaired in MS subjects, suggesting that an abnormal coronary microvascular response occurred in these subjects. This abnormality may have been partially due to insulin resistance and hypertension. |
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Authors:
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Hiroki Teragawa; Koichi Morita; Hiroki Shishido; Nobuaki Otsuka; Yutaka Hirokawa; Kazuaki Chayama; Nagara Tamaki; Yasuki Kihara |
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Publication Detail:
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Type: Journal Article Date: 2009-11-14 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 37 ISSN: 1619-7089 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-07-14 Completed Date: 2010-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 368-76 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Minami-ku, Hiroshima, Japan. hteraga@hiroshima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ammonia
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diagnostic use* Coronary Circulation* Coronary Vessels / physiopathology Humans Male Metabolic Syndrome X / physiopathology*, radiography, radionuclide imaging*, ultrasonography Middle Aged Nitrogen Radioisotopes / diagnostic use Positron-Emission Tomography* Retrospective Studies Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Nitrogen Radioisotopes; 7664-41-7/Ammonia |
| Comments/Corrections | |
Erratum In:
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Eur J Nucl Med Mol Imaging. 2010 Aug;37(9):1794-5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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