| Impaired myocardial autophagy linked to energy metabolism disorders. | |
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MedLine Citation:
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PMID: 22722538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autophagy represents an evolutionarily conserved catabolic mechanism that promotes cell survival by releasing energy substrates via degradation of cellular constituents and by eliminating defective organelles under conditions of stress, such as starvation and hypoxia. The link between enhanced autophagy and nutrient deprivation has been well established. For example, chronic myocardial ischemia, a condition of insufficient oxygen and nutrition, activates autophagy to degrade and recycle damaged cellular structures, thereby ameliorating cardiomyocyte injury. |
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Authors:
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Zi-Lun Li; Lilach O Lerman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-06-01 |
Journal Detail:
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Title: Autophagy Volume: 8 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-08-24 Completed Date: 2013-01-03 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 992-4 Citation Subset: IM |
Affiliation:
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Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autophagy* Energy Metabolism* Humans Insulin Resistance Metabolic Syndrome X / pathology* Models, Biological Myocardium / pathology* Sirtuin 1 / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK73608/DK/NIDDK NIH HHS; HL085307/HL/NHLBI NIH HHS; HL77131/HL/NHLBI NIH HHS; R01 DK073608/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.5.1.-/Sirtuin 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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