Document Detail

Impaired midwall mechanics and biventricular hypertrophy in essential hypertension.
MedLine Citation:
PMID:  20218917     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Impaired left ventricular (LV) mechanics in human hypertension are strongly related to LV hypertrophy (LVH). In the present study, we investigated the relationship between LV mid-wall fractional shortening (MWS) and biventricular hypertrophy in uncomplicated essential hypertensives.
METHODS: A total of 328 hypertensive patients categorized in tertiles of MWS were considered for the analysis. All patients underwent routine and standardized echocardiographic examinations. Biventricular hypertrophy was defined by anterior right ventricular (RV) wall thickness >or=3.1 mm/m(2) in men and >or=3.0 mm/m(2) in women, combined with LV mass index (LVMI) >or=49 g/m(2.7) in men and 45 g/m(2.7) in women.
RESULTS: Biventricular hypertrophy was found in 21% of the study population. In the lowest MWS tertile, the likelihood of biventricular hypertrophy was 1.4- and 1.9-fold greater (p<0.05) than in the intermediate and highest one, respectively; this was not the case for isolated LVH or RV hypertrophy (RVH). In a multivariate analysis, MWS was significantly associated with LV mass index (beta=-0.181, p=0.003) and RV wall thickness (beta=-0.171, p50.01).
CONCLUSION: In systemic hypertension, a decrease in LV systolic performance may be related not only to LVH, but to the global cardiac involvement occurring in biventricular hypertrophy.
Cesare Cuspidi; Francesca Negri; Valentina Giudici; Carla Sala; Giuseppe Mancia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  19     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  234-9     Citation Subset:  IM    
Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milano, Italy.
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MeSH Terms
Heart Ventricles / pathology
Hypertension / complications*,  physiopathology,  ultrasonography
Hypertrophy, Left Ventricular / etiology*,  physiopathology,  ultrasonography
Hypertrophy, Right Ventricular / etiology*,  physiopathology,  ultrasonography
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