| Impaired local production of pro-resolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. | |
| | |
MedLine Citation:
|
PMID: 23349501 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Obesity-induced chronic low-grade inflammation originates from adipose tissue and is crucial for obesity-driven metabolic deterioration including insulin resistance and type 2 diabetes.Chronic inflammation may be a consequence of a failure to actively resolve inflammation,and could result from a lack of local specialized pro-resolving lipid mediators (SPM) such as resolvins and protectins, which derive from the n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We assessed obesity-induced changes of n-3-derived SPM in adipose tissue and effects of dietary EPA/DHA thereon.Moreover, we treated obese mice with SPM precursors and investigated effects on inflammation and metabolic dysregulation. Obesity significantly decreased DHA-derived 17-hydroxydocosahexaenoic acid (17-HDHA, resolvin D1 precursor) and protectin D1 levels in murine adipose tissue. Dietary EPA/DHA treatment restored endogenous biosynthesis of n-3 derived lipid mediators in obesity while attenuating adipose tissue inflammation and improving insulin sensitivity. Notably, 17-HDHA treatment reduced adipose tissue expression of inflammatory cytokines, increased adiponectin expression and improved glucose tolerance parallel to insulin sensitivity in obese mice. These findings indicate that impaired biosynthesis of certain SPM and SPM precursors including 17-HDHA and protectin D1 contributes to adipose tissue inflammation in obesity and suggest 17-HDHA as a novel treatment option for obesity-associated complications. |
| | |
Authors:
|
Angelika Neuhofer; Maximilian Zeyda; Daniel Mascher; Bianca K Itariu; Incoronata Murano; Lukas Leitner; Eva E Hochbrugger; Peter Fraisl; Saverio Cinti; Charles N Serhan; Thomas M Stulnig |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-24 |
Journal Detail:
|
Title: Diabetes Volume: - ISSN: 1939-327X ISO Abbreviation: Diabetes Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372763 Medline TA: Diabetes Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ?-Cell-Specific Protein Kinase A Activation Enhances the Efficiency of Glucose Control by Increasing...
Next Document: Cbl-b Is a Critical Regulator of Macrophage Activation Associated with Obesity-Induced Insulin Resis...