| Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1. | |
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MedLine Citation:
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PMID: 20669273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD-specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA-insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1. |
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Authors:
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Nebojsa M Lalić; Natasa Dragasević; Elka Stefanova; Aleksandra Jotić; Katarina Lalić; Tanja Milicić; Igor Petrović; Marija Maćesić; Vladimir S Kostić |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 25 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 1976-80 Citation Subset: IM |
Copyright Information:
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© 2010 Movement Disorder Society. |
Affiliation:
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Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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metabolism Cholesterol, LDL / blood Glucose Clamp Technique Glucose Tolerance Test Humans Insulin / metabolism*, secretion* Insulin Resistance* Spinocerebellar Ataxias / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, LDL; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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