Document Detail


Impaired insulin secretion in perfused pancreases isolated from offspring of female rats fed a low protein whey-based diet.
MedLine Citation:
PMID:  18648139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Insufficient maternal protein intake has been postulated to cause impaired fuel metabolism and diabetes mellitus in adult mammalian progeny, but the mechanism remains unclear. OBJECTIVE: To investigate the effect of a maternal low protein whey-based diet during pregnancy and lactation on pancreatic function and skeletal muscle glucose metabolism in the offspring. ANIMALS: Sprague-Dawley rats: 8 mothers and 46 offspring. DESIGN: Female rats were fed throughout pregnancy and lactation with otherwise-complete isoenergetic diets sufficient (20% whey protein; control: n=3) or insufficient (5% whey protein; low-protein: n=5) in whey protein. From weaning all offspring ate control diet. MAIN OUTCOME MEASURES: Food intake and weight gain were measured for both mothers and offspring, and in vitro functional studies of endocrine pancreas and skeletal muscle were performed on offspring at 40 and 50 days of age, respectively. RESULTS: Food intake (P=0.004) and weight gain (P=0.006) were lower in low protein than control mothers during early gestation. Offspring of low protein mothers had significant lower body weight from 5 to 15 days of age, although there was no significant difference in food consumption. Glucose, arginine- and glucose/arginine-stimulated insulin secretion from perfused pancreases isolated from low protein offspring were decreased by between 55 and 65% compared with control values. Studies in skeletal muscle demonstrated no difference in insulin sensitivity between the two groups. CONCLUSIONS: Dietary whey protein insufficiency in female rats during pregnancy and lactation can evoke major changes in insulin secretion in progeny, and these changes represent a persistent functional abnormality in the endocrine pancreas.
Authors:
Matthew P G Barnett; Anthony R J Phillips; Patricia M Harris; Garth J S Cooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-10
Journal Detail:
Title:  JOP : Journal of the pancreas     Volume:  9     ISSN:  1590-8577     ISO Abbreviation:  JOP     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-23     Completed Date:  2008-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101091810     Medline TA:  JOP     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  477-88     Citation Subset:  IM    
Affiliation:
School of Biological Sciences, Faculty of Science, The University of Auckland, Auckland, New Zealand. matthew.barnett@agresearch.co.nz
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Blood Glucose
Body Weight
Diet, Protein-Restricted* / adverse effects
Eating
Female
Glucose / metabolism,  pharmacokinetics
Glycogen / metabolism
Insulin / biosynthesis,  pharmacology,  secretion*
Lactation / metabolism
Male
Milk Proteins / adverse effects*
Mothers
Muscle, Skeletal / drug effects,  metabolism
Organ Culture Techniques
Pancreas / metabolism,  secretion*
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Rats, Sprague-Dawley
Weight Gain
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Milk Proteins; 0/whey protein; 11061-68-0/Insulin; 50-99-7/Glucose; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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