| Impaired incretin effect and fasting hyperglucagonaemia characterising type 2 diabetic subjects are early signs of dysmetabolism in obesity. | |
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MedLine Citation:
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PMID: 22171657 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims : People with type 2 diabetes mellitus (T2DM) are characterised by reduced incretin effect and inappropriate glucagon levels. We evaluated alpha and beta cell responses to oral glucose tolerance test (OGTT) and isoglycaemic i.v. glucose infusion (IIGI) in lean and obese persons with T2DM or normal glucose tolerance (NGT) to elucidate the impact of obesity on the incretin effect and incretin hormone and glucagon responses. Materials and methods : 4-hour 50 g-OGTT and IIGI were performed in: 1) Eight obese patients with T2DM (mean body mass index (BMI): 37(range: 35-41) kg/m(2) ); 2) Eight obese subjects with NGT (BMI: 33(35-38) kg/m(2) ); 3) Eight lean patients with T2DM (BMI: 24(22-25) kg/m(2) ); and 4) Eight lean healthy subjects (BMI: 23(20-25) kg/m(2) ). Results : The incretin effect was significantly (P<0.05) reduced in patients with T2DM (obese: 7±7% (mean±s.e.m.); lean: 29±8%; P=0.06)) and was lower in obese subjects (41±4%) than in lean subjects with NGT (53±4%; P<0.05). Obese subjects with NGT were also characterised by elevated fasting plasma glucagon levels, but the inappropriate glucagon responses to OGTT found in the T2DM patients were not evident in these subjects. Conclusions : Our findings suggest that reduced incretin effect and fasting hyperglucagonaemia constitute very early steps in the pathophysiology of T2DM detectable even in obese people who despite their insulin resistant state have NGT. |
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Authors:
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Filip K Knop; Kasper Aaboe; Tina Vilsbøll; Aage Vølund; Jens J Holst; Thure Krarup; Sten Madsbad |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-15 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Internal Medicine, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark Department of Biomedical Sciences, the Panum Institute, University of Copenhagen, Copenhagen, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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