| Impaired in vivo dopamine release in parkin knockout mice. | |
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MedLine Citation:
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PMID: 20620130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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parkin is the most frequent causative gene among familial Parkinson's disease (PD). Although parkin deficiency induces autosomal recessive juvenile parkinsonism (AR-JP, PARK2) in humans, parkin knockout (PKO) mice consistently show few signs of dopaminergic degeneration. We aimed to directly measure evoked extracellular dopamine (DA) overflow in the striatum with in vivo voltammetry. The amplitude of evoked DA overflow was low in PKO mice. The half-life time of evoked DA overflow was long in PKO mice suggesting lower release and uptake of dopamine. Facilitation of DA overflow by repetitive stimulation enhanced in the older PKO mice. Decreased dopamine release and uptake in young PKO mice suggest early pre-symptomatic changes in dopamine neurotransmission, while the enhanced facilitation in the older PKO mice may reflect a compensatory adaptation in dopamine function during the late pre-symptomatic phase of Parkinson's disease. Our results showed parkin deficiency may affect DA release in PKO mice, although it does not cause massive nigral degeneration or parkinsonian symptoms as in humans. |
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Authors:
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Genko Oyama; Kenji Yoshimi; Shihoko Natori; Yoko Chikaoka; Yong-Ri Ren; Manabu Funayama; Yasushi Shimo; Ryosuke Takahashi; Taizo Nakazato; Shigeru Kitazawa; Nobutaka Hattori |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-08 |
Journal Detail:
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Title: Brain research Volume: 1352 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 214-22 Citation Subset: IM |
Affiliation:
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Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Aging / physiology Animals Body Weight Corpus Striatum / physiology* Dopamine / metabolism*, secretion* Homovanillic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Mice Mice, Knockout Motor Activity / physiology Nerve Fibers / drug effects, physiology Nomifensine / pharmacology Prosencephalon / drug effects, physiology Ubiquitin-Protein Ligases / deficiency* |
| Chemical | |
Reg. No./Substance:
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102-32-9/3,4-Dihydroxyphenylacetic Acid; 24526-64-5/Nomifensine; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; EC 6.3.2.19/Ubiquitin-Protein Ligases; EC 6.3.2.19/parkin protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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