| Impaired hippocampal neurogenesis and vascular formation in ephrin-A5-deficient mice. | |
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MedLine Citation:
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PMID: 20474079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurogenesis occurs throughout the life in the mammalian brain. The hippocampal dentate gyrus (DG) is one of the major regions of the adult neurogenesis, where neural stem/progenitor cells continuously generate new granule neurons, although molecular mechanisms underlying generation and maintenance of newly born neurons are still elusive. Here we show that ephrin-A5, a ligand for Eph receptor tyrosine kinases, plays multiple roles in both neurogenesis and vascular formation in the adult hippocampus. In mice lacking ephrin-A5 function, cell proliferation and survival of newborn neurons were severely reduced in the hippocampus DG. Furthermore, ephrin-A5-deficient mice exhibited altered distribution of EphA4 receptor in the vascular endothelial cells and increased narrower capillaries in the hippocampus DG. EphA/ephrin-A signaling thus plays crucial roles in the establishment and/or maintenance of the brain vascular system, as an essential constituent of the adult neurogenic niche. |
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Authors:
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Yoshinobu Hara; Tadashi Nomura; Kaichi Yoshizaki; Jonas Frisén; Noriko Osumi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Stem cells (Dayton, Ohio) Volume: 28 ISSN: 1549-4918 ISO Abbreviation: Stem Cells Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304532 Medline TA: Stem Cells Country: United States |
Other Details:
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Languages: eng Pagination: 974-83 Citation Subset: IM |
Affiliation:
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Division of Developmental Neuroscience, Core Center for Neuroscience, ART, Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Stem Cells
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cytology,
metabolism* Aging / genetics Animals Cell Proliferation Cell Survival / genetics Down-Regulation / genetics Endothelium, Vascular / metabolism, pathology Ephrin-A5 / genetics* Hippocampus / cytology, metabolism* Mice Mice, Inbred C57BL Mice, Knockout Neovascularization, Pathologic / genetics, metabolism*, pathology* Neurogenesis / physiology* Receptors, Eph Family / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Ephrin-A5; EC 2.7.10.1/Receptors, Eph Family |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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