Document Detail


Impaired gustatory neophobia following traumatic brain injury in rats.
MedLine Citation:
PMID:  7473805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the function of the amygdala following traumatic brain injury (TBI), rats were tested on a gustatory neophobia task that is sensitive to amygdala and hippocampal damage. Rats were either injured at a moderate level of fluid percussion injury (2.1 atm) or surgically prepared but not injured (sham-injury). Seven days after injury (n = 8) or sham injury (n = 9), rats were habituated to the testing chamber without food items present for 30 min. All rats were then food deprived. Twenty-four hours later, rats were placed in the testing chamber for 30 min and allowed to eat freely from four dishes of different foods: rat chow, raisins, potatoes, and cookies. Results showed that injured and sham-injured rats did not differ in their ability to find hidden food, suggesting that TBI does not produce an enduring impairment of olfaction. There was also no difference in the total amount of food eaten between injured and sham groups (p > 0.05). The percentage of each type of food consumed did differ between the two groups with sham controls consuming more familiar food (rat chow) compared to the unfamiliar foods (p < 0.01). The injured animals distributed their eating evenly among the four foods with no particular preference for any one food (p < 0.05). This pattern of eating behavior in injured animals is similar to animals that have lesions to both the hippocampus and amygdala (Sutherland and McDonald, 1990). Therefore, the results of this experiment suggest that, in addition to the hippocampus, the amygdala may also contribute to the behavioral changes observed following TBI.
Authors:
R J Hamm; B R Pike; L L Phillips; D M O'dell; M D Temple; B G Lyeth
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurotrauma     Volume:  12     ISSN:  0897-7151     ISO Abbreviation:  J. Neurotrauma     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-30     Completed Date:  1995-11-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-14     Citation Subset:  IM    
Affiliation:
Department of Psychology, Virginia Commonwealth University/Medical College of Virginia, Richmond, USA.
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MeSH Terms
Descriptor/Qualifier:
Amygdala / pathology*
Animals
Brain Injuries / pathology*
Eating*
Hippocampus / pathology*
Male
Rats
Rats, Sprague-Dawley
Smell
Task Performance and Analysis
Grant Support
ID/Acronym/Agency:
NS-12857/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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