Document Detail

Impaired granulocyte oxidative burst and decreased expression of leucocyte adhesion molecule-1 (LAM-1) in patients with Wegener's granulomatosis.
MedLine Citation:
PMID:  7512009     Owner:  NLM     Status:  MEDLINE    
Neutrophils are the target of autoantibodies in Wegener's granulomatosis (WG). In this study, granulocyte function and surface marker expression were investigated in patients with WG. The oxidative burst in response to phorbol myristate acetate (PMA) was tested with granulocytes of 25 patients with histologically proven WG. A significantly diminished percentage of oxygen radical-producing cells was found in patients with active disease. Surface antigen expression of CD11b and LAM-1 was analysed on granulocytes of 20 patients with WG. Whereas the expression of CD11b was normal, surface expression of LAM-1 was decreased in nine cases with WG. The decrease of LAM-1 correlated with disease activity. Phagocytosis of Escherichia coli was tested in 10 patients with WG, and normal values were found in all cases. We conclude that down-regulation of LAM-1 may be a marker of disease activity in WG. The altered response to PMA may indicate functional changes in granulocyte reactivity due to autoantibody-induced damage of the granulocyte membrane.
B Riecken; J Gutfleisch; M Schlesier; H H Peter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  96     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-12     Completed Date:  1994-05-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
Department of Medicine, University Hospital Freiburg, Germany.
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MeSH Terms
Cell Adhesion Molecules / metabolism*
Neutrophils / physiology*
Respiratory Burst
Wegener Granulomatosis / physiopathology*
Reg. No./Substance:
0/Cell Adhesion Molecules; 126880-86-2/L-Selectin

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