| Impaired granulocyte adherence in mildly diabetic patients: effects of tolazamide treatment. | |
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MedLine Citation:
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PMID: 7358229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Granulocyte adherence in 10 of 15 untreated asymptomatic hyperglycemic diabetic outpatients (mean fasting glucose +/- SEM, 289 +/- 16 mg/100 ml) was 62 +/- 7% of control values. After treatment (2--4 wk) with tolazamide (500 mg daily), adherence to the nylon fiber columns employed in this study returned to control levels in the seven patients whose fasting glucose levels fell, (mean, 192 +/- 16 mg/100 ml) and deteriorated in the three in whom fasting hyperglycemia worsened. Results of this study indicate that, even in some mildly diabetic patients, a reduction in granulocyte adherence similar to that found in insulin-dependent diabetics may impair the inflammatory response. |
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Authors:
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J D Bagdade; E Walters |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Diabetes Volume: 29 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1980 Apr |
Date Detail:
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Created Date: 1980-05-30 Completed Date: 1980-05-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 309-11 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Adhesion Diabetes Mellitus / drug therapy, physiopathology* Female Granulocytes / drug effects, physiology* Humans Male Tolazamide / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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1156-19-0/Tolazamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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