Document Detail

Impaired granulocyte adherence in mildly diabetic patients: effects of tolazamide treatment.
MedLine Citation:
PMID:  7358229     Owner:  NLM     Status:  MEDLINE    
Granulocyte adherence in 10 of 15 untreated asymptomatic hyperglycemic diabetic outpatients (mean fasting glucose +/- SEM, 289 +/- 16 mg/100 ml) was 62 +/- 7% of control values. After treatment (2--4 wk) with tolazamide (500 mg daily), adherence to the nylon fiber columns employed in this study returned to control levels in the seven patients whose fasting glucose levels fell, (mean, 192 +/- 16 mg/100 ml) and deteriorated in the three in whom fasting hyperglycemia worsened. Results of this study indicate that, even in some mildly diabetic patients, a reduction in granulocyte adherence similar to that found in insulin-dependent diabetics may impair the inflammatory response.
J D Bagdade; E Walters
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes     Volume:  29     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  309-11     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Adhesion
Diabetes Mellitus / drug therapy,  physiopathology*
Granulocytes / drug effects,  physiology*
Tolazamide / therapeutic use*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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