Document Detail

Impaired glucose tolerance worsens exercise capacity and ventilatory response to exercise in patients with chronic heart failure.
MedLine Citation:
PMID:  17530558     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is increasing evidence for the importance of peripheral abnormalities in the pathogenesis and progression of heart failure (HF). Recently, glucose and insulin metabolism abnormalities have been intensively investigated in patients with HF. AIM: To investigate whether coexistence of impaired glucose tolerance (IGT) may decrease exercise tolerance and influence ventilatory response to exercise in patients with systolic HF. METHODS: Maximal cardiopulmonary exercise test with evaluation of peak VO2 and VE/VCO2 slope and oral glucose tolerance test were performed in 64 clinically stable patients with HF and LVEF <45%. RESULTS: Impaired glucose tolerance was diagnosed in 26 (41%) patients and normal glucose tolerance (NGT) in 38 (59%) patients. There were no significant differences in baseline clinical characteristics or LVEF between groups. There were significant differences in peak VO2 between IGT and NGT (15.4+/-4.1 vs. 18.7+/-4.2 ml/kg/min respectively; p=0.003) and VE/VCO2 slope (35.7+/-7.3 vs. 31.8+/-5.7 respectively; p=0.02). The IGT was independently related to peak VO2 and VE/VCO2 slope in multivariate regression analysis. CONCLUSION: The IGT is associated with worse exercise capacity and ventilatory response to exercise in patients with HF.
Ewa Straburzyńska-Migaj; Romuald Ochotny; Andrzej Cieśliński
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Kardiologia polska     Volume:  65     ISSN:  0022-9032     ISO Abbreviation:  Kardiol Pol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-08-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376352     Medline TA:  Kardiol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  354-60; discussion 361-2     Citation Subset:  IM    
1st Department, Poznan University of Medical Sciences, Poland.
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MeSH Terms
Chronic Disease
Exercise Test
Exercise Tolerance / physiology*
Glucose Intolerance / physiopathology*
Glucose Tolerance Test
Heart Failure / physiopathology*
Middle Aged
Oxygen Consumption
Pulmonary Ventilation / physiology*

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