Document Detail


Impaired glucose homeostasis during postimplantation pregnancy in the mouse following acute exposure to ethanol, with particular reference to the uterus and embryo.
MedLine Citation:
PMID:  1562357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dramatic changes in the levels of plasma glucose and lactate and liver glycogen were observed in mice, given an intraperitoneal injection of ethanol (3.5 g/kg body weight) on Day 9 of pregnancy, during the period of time (6 h) required to clear the drug from the circulatory system. These alterations were accompanied by significant changes in the rates of accumulation of some glycolytic and citric acid cycle intermediates in the uterus, including glucose-6-phosphate, fructose-6-phosphate, lactate, citrate, alpha-ketoglutarate, and succinate. Although the changes in some metabolic parameters were very transient, not all metabolites returned to control values by the time that the drug had been cleared from the maternal system. Alcohol also impaired the capacity of Day 9 mouse embryos to metabolize [14C]glucose under culture conditions in vitro and significantly increased the amount of the aldohexose accumulating in the fetal membrane fluid when administered on Day 14 of pregnancy. However, ethanol neither influenced the ratio of NADH to NAD+ in the uterus nor changed the glycolytic and respiratory activity of the uterine endometrium when coincubated with the tissue in vitro. The results indicate that glucose homeostasis is impaired in both the embryo and the maternal system of mice acutely exposed to alcohol during the teratogenically sensitive period of postimplantation pregnancy and support the thesis that this phenomenon may present an important mechanism underlying the embryo-toxic effects of alcohol consumed under "binge" drinking conditions during pregnancy. However, the results also suggest that the effects registered at the uterine level most likely involve stress reactions and acetate rather than primary actions of the drug on the organ.
Authors:
R N Murdoch; B Simm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical medicine and metabolic biology     Volume:  47     ISSN:  0885-4505     ISO Abbreviation:  Biochem. Med. Metab. Biol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-15     Completed Date:  1992-05-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8605718     Medline TA:  Biochem Med Metab Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  54-65     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, University of Newcastle, New South Wales, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Citrates / metabolism
Citric Acid
Embryo, Mammalian / drug effects,  metabolism*
Ethanol / pharmacology*,  toxicity
Female
Glucose / metabolism*
Glycogen / metabolism
Hexosephosphates / metabolism
Homeostasis / drug effects*
Kinetics
Lactates / blood,  metabolism
Lactic Acid
Liver / metabolism
Mice
Pregnancy
Uterus / drug effects,  metabolism*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Citrates; 0/Hexosephosphates; 0/Lactates; 50-21-5/Lactic Acid; 50-99-7/Glucose; 64-17-5/Ethanol; 77-92-9/Citric Acid; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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