| Impaired flow-mediated endothelium-dependent and endothelium-independent vasodilation of the brachial artery in patients with atherosclerotic peripheral vascular disease. | |
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MedLine Citation:
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PMID: 18319222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A flow-mediated endothelium-dependent vasodilation and endothelium-independent nitroglycerin-induced vasodilation were carried out in 70 patients and 15 age-matched adults without any atherosclerotic risk factors to clarify vascular responsiveness in patients with atherosclerotic peripheral vascular disease. The percent change in flow-mediated vasodilation was significantly lower in patients than in controls (5.4 +/- 0.7% vs 12.8 +/- 2.2%, P < .001). Moreover, the percent change in nitroglycerin-induced vasodilation measured after sublingual administration of nitroglycerin was lower in patients than in controls (5.8 +/- 0.6% vs 10.2 +/- 1.5%, P < .01). On multiple regression analysis, none of the determinant factors showed a significant correlation with flow-mediated vasodilation. In contrast, Fontaine classification was found to be a significant predictor for nitroglycerin-induced vasodilation (r = -0.307, P < .05). There is a significant positive correlation between nitroglycerin-induced vasodilation and ankle-brachial pressure index in the patients. The data showed that vasoditation function were markedly impaired in end-stage patients with peripheral vascular disease. |
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Authors:
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Hiroyoshi Komai; Yayoi Higami; Hisaharu Tanaka; Kentaro Honda; Masanobu Juri; Yoshitaka Okamura |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Angiology Volume: 59 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2008 Feb-Mar |
Date Detail:
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Created Date: 2008-03-05 Completed Date: 2008-04-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 52-6 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Saiseikai Wakayama Hospital, Wakayama 640-8158, Japan. komai-ths@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Ankle / blood supply Atherosclerosis / physiopathology* Blood Pressure Brachial Artery / physiopathology* Case-Control Studies Endothelium, Vascular / physiopathology* Female Humans Hyperemia / physiopathology Male Middle Aged Nitroglycerin / diagnostic use Peripheral Vascular Diseases / physiopathology* Prognosis Regional Blood Flow Severity of Illness Index Vasodilation* Vasodilator Agents / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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