Document Detail

Impaired flow-mediated endothelium-dependent and endothelium-independent vasodilation of the brachial artery in patients with atherosclerotic peripheral vascular disease.
MedLine Citation:
PMID:  18319222     Owner:  NLM     Status:  MEDLINE    
A flow-mediated endothelium-dependent vasodilation and endothelium-independent nitroglycerin-induced vasodilation were carried out in 70 patients and 15 age-matched adults without any atherosclerotic risk factors to clarify vascular responsiveness in patients with atherosclerotic peripheral vascular disease. The percent change in flow-mediated vasodilation was significantly lower in patients than in controls (5.4 +/- 0.7% vs 12.8 +/- 2.2%, P < .001). Moreover, the percent change in nitroglycerin-induced vasodilation measured after sublingual administration of nitroglycerin was lower in patients than in controls (5.8 +/- 0.6% vs 10.2 +/- 1.5%, P < .01). On multiple regression analysis, none of the determinant factors showed a significant correlation with flow-mediated vasodilation. In contrast, Fontaine classification was found to be a significant predictor for nitroglycerin-induced vasodilation (r = -0.307, P < .05). There is a significant positive correlation between nitroglycerin-induced vasodilation and ankle-brachial pressure index in the patients. The data showed that vasoditation function were markedly impaired in end-stage patients with peripheral vascular disease.
Hiroyoshi Komai; Yayoi Higami; Hisaharu Tanaka; Kentaro Honda; Masanobu Juri; Yoshitaka Okamura
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  59     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2008 Feb-Mar
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-6     Citation Subset:  IM    
Department of Cardiovascular Surgery, Saiseikai Wakayama Hospital, Wakayama 640-8158, Japan.
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MeSH Terms
Aged, 80 and over
Ankle / blood supply
Atherosclerosis / physiopathology*
Blood Pressure
Brachial Artery / physiopathology*
Case-Control Studies
Endothelium, Vascular / physiopathology*
Hyperemia / physiopathology
Middle Aged
Nitroglycerin / diagnostic use
Peripheral Vascular Diseases / physiopathology*
Regional Blood Flow
Severity of Illness Index
Vasodilator Agents / diagnostic use
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

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