Document Detail

Impaired fatty acid oxidation in propofol infusion syndrome.
MedLine Citation:
PMID:  11558490     Owner:  NLM     Status:  MEDLINE    
Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children given long-term propofol infusions. We describe a child who developed all the clinical features of propofol infusion syndrome and was treated successfully with haemofiltration. Biochemical analysis before haemofiltration showed a large rise in plasma concentrations of malonylcarnitine (3.3 micromol/L) and C5-acylcarnitine (8.4 micromol/L), which returned to normal after recovery. Abnormalities are consistent with specific disruption of fatty-acid oxidation caused by impaired entry of long-chain acylcarnitine esters into the mitochondria and failure of the mitochondrial respiratory chain at complex 11.
A Wolf; P Weir; P Segar; J Stone; J Shield
Publication Detail:
Type:  Case Reports; Letter    
Journal Detail:
Title:  Lancet     Volume:  357     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-09-17     Completed Date:  2001-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  606-7     Citation Subset:  AIM; IM    
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MeSH Terms
Acidosis / chemically induced*,  metabolism,  therapy*
Carnitine / blood
Critical Care
Electron Transport / drug effects
Fatty Acids / metabolism*
Hypnotics and Sedatives / administration & dosage,  adverse effects*
Infusions, Intravenous
Propofol / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Fatty Acids; 0/Hypnotics and Sedatives; 2078-54-8/Propofol; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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