| Impaired exercise performance after successful liver transplantation. | |
| | |
MedLine Citation:
|
PMID: 11579319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Recipients of heart, lung, and kidney transplants have impaired peak exercise performance (peak Vo2 40% to 60% predicted, reduced anaerobic threshold [AT]) without evidence of ventilatory or cardiac limitations. The aim of this study was to determine whether similar exercise impairment occurs in liver transplant recipients. METHODS: We studied eight healthy liver transplant recipients (age 42+/-9 [SD] years, 6 male, 31+/-13 months posttransplant). Immunosuppression included FK506 or cyclosporine, azathioprine or mycophenolate mofetil, and prednisone. Subjects underwent lung function testing and cardiopulmonary exercise testing on a cycle ergometer. RESULTS: Peak exercise oxygen consumption (Vo2) was 22+/-8 ml/min/kg (66+/-20% predicted maximum). No subject demonstrated exercise desaturation or ventilatory limitation (peak minute ventilation 55+/-8% predicted maximum voluntary ventilation). Peak heart rate was 87+/-8% of predicted maximum. Early AT was evident (1.2+/-0.34 L/min, 48+/-11% predicted Vo2max). CONCLUSIONS: Liver transplant recipients exhibit impaired peak exercise performance similar to that observed after other solid organ transplants, possibly as a result of chronic deconditioning or myopathy related to immunosuppressive medications. |
| | |
Authors:
|
A L Stephenson; E M Yoshida; R T Abboud; G Fradet; R D Levy |
Related Documents
:
|
17306899 - Combining peak oxygen consumption and ventilatory efficiency in the prognostic assessme... 17068219 - Maximal oxygen uptake is not limited by a central nervous system governor. 18545199 - Identification of a vo2 deflection point coinciding with the heart rate deflection poin... 21688869 - Carbohydrate ingestion during team games exercise: current knowledge and areas for futu... 15029939 - The effects of graded forward and backward walking on heart rate and oxygen consumption. 1563059 - Amrinone before termination of cardiopulmonary bypass: haemodynamic variables and oxyge... 2633969 - Synovial fluid changes in mycoplasma induced septicaemic polyarthritis of goat kids. 18768359 - Sex difference in peak oxygen uptake in prepubertal children. 11889199 - Hypocaloric diet reduces exercise-induced alpha 2-adrenergic antilipolytic effect and a... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Transplantation Volume: 72 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 2001 Sep |
Date Detail:
|
Created Date: 2001-10-01 Completed Date: 2001-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
|
Languages: eng Pagination: 1161-4 Citation Subset: IM |
Affiliation:
|
Respiratory Division, Vancouver General Hospital, 2775 Heather Street, Vancouver, BC, Canada, V5Z 3J5. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Exercise Test Female Heart Rate Humans Liver Transplantation* Male Middle Aged Oxygen Consumption Physical Endurance* Postoperative Period Respiratory Function Tests |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytotoxic effector molecule gene expression in acute renal allograft rejection: correlation with cli...
Next Document: Hope versus efficiency in organ allocation.