Document Detail


Impaired exercise capacity and exercise training in maintenance hemodialysis patients.
MedLine Citation:
PMID:  15648006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with advanced chronic renal failure, including those undergoing maintenance hemodialysis (MHD), commonly suffer from sarcopenia and reduced physical exercise capacity. The causes of these disorders include anemia, cardiovascular and pulmonary diseases, other comorbid conditions, altered skeletal muscle metabolism, myopathic changes that are associated with chronic renal failure per se, malnutrition, and physical deconditioning. Exercise training has been shown to increase exercise capacity and, in some studies, to increase muscle mass. In our experience, cardiopulmonary fitness training of sedentary MHD patients for an average of 8.6 weeks using a stationary ergometer increased endurance capacity, physical performance, and physical strength in the lower extremities, and in particular, quadriceps strength, power, and fatigability. This surprising finding of increased lower-extremity strength with cardiovascular fitness training may reflect the possibility that the MHD patients were so deconditioned that the small amount of resistance encountered with pedaling a stationary ergometer increased their physical strength. By the end of the endurance exercise training program, the MHD patients also showed changes in the right vastus lateralis muscle for the mRNA levels of a number of proteins involved with skeletal muscle protein synthesis and hypertrophy. The mRNA levels changed in a direction that would be expected to promote protein accrual and hypertrophy of skeletal muscle. These findings indicate that in sedentary MHD patients endurance exercise training for a few weeks can result in improved exercise capacity and a pattern of transcriptional factors that may promote an increase in skeletal muscle mass.
Authors:
Joel D Kopple; Tom Storer; Richard Casburi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  15     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-13     Completed Date:  2006-08-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-8     Citation Subset:  IM    
Affiliation:
Harbor-UCLA Medical Center, Torrance, CA 90509, USA.
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MeSH Terms
Descriptor/Qualifier:
Anemia / complications
Exercise / physiology*
Exercise Therapy
Growth Substances / genetics
Humans
Kidney Failure, Chronic / physiopathology*,  therapy
Malnutrition / complications
Muscle Proteins / biosynthesis
Muscle, Skeletal / chemistry,  metabolism
Physical Endurance
Physical Fitness
RNA, Messenger / analysis
Renal Dialysis*
Grant Support
ID/Acronym/Agency:
5 R01 DK54457-04/DK/NIDDK NIH HHS; M01-RROO425/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Growth Substances; 0/Muscle Proteins; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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