Document Detail

Impaired endothelial function with essential hypertension assessed by ultrasonography.
MedLine Citation:
PMID:  8831366     Owner:  NLM     Status:  MEDLINE    
The objective of this investigation was to evaluate the role of hypertension in endothelial function, changes in which are known to be an early event of atherosclerosis. We assessed endothelial function in 13 subjects with normal blood pressure and 13 subjects with essential hypertension who had never been treated for hypertension or hyperlipidemia and who had no history of smoking or coronary or cerebrovascular disease. B-mode ultrasonography was used to measure the diameter of the brachial artery. Endothelium-dependent dilatation was assessed as the change in diameter of the artery during reactive hyperemia. Endothelium-independent dilatation was evoked, as a control, by sublingual administration of isosorbide dinitrate. Despite similar ages and lipid and glucose levels in the study groups, endothelium-dependent dilatation was less in patients with hypertension (13.1% +/- 1.6%) than in subjects with normal blood pressure (18.5% +/- 1.9%) (p < 0.05), whereas isosorbide dinitrate-induced changes were similar. Systolic and diastolic blood pressure were significantly correlated with endothelium-dependent vasodilatation (r = -0.57 and r = -0.53, respectively) but not with the change by isosorbide dinitrate. These results suggest that endothelial dysfunction exists in patients with hypertension and precedes overt atherosclerotic disease.
K Iiyama; M Nagano; Y Yo; N Nagano; K Kamide; J Higaki; H Mikami; T Ogihara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  132     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-01     Completed Date:  1996-11-01     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  779-82     Citation Subset:  AIM; IM    
Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan.
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MeSH Terms
Arteriosclerosis / etiology
Brachial Artery / drug effects,  physiopathology,  ultrasonography*
Case-Control Studies
Endothelium, Vascular / physiopathology,  ultrasonography*
Hyperemia / physiopathology
Hypertension / physiopathology,  ultrasonography*
Isosorbide Dinitrate / diagnostic use
Middle Aged
Vasodilator Agents / diagnostic use
Reg. No./Substance:
0/Vasodilator Agents; 87-33-2/Isosorbide Dinitrate

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