Document Detail


Impaired endothelial-dependent forearm vascular relaxation in black Americans.
MedLine Citation:
PMID:  10223778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hypertension is a major cause of morbidity and mortality in the general population and has an even more significant impact on the black community in particular. Explaining the interethnic differences has been difficult. Differences in endothelial function may provide some insight into the causes of the increased incidence of hypertension in the black population versus their white cohorts. METHODS: In this study 16 black subjects and 12 white subjects received brachial artery infusions of acetylcholine (12.5, 25, and 50 microg/min) and angiotensin II (3.82, 9.55, and 19.10 ng/min). Measurement of forearm vascular resistance by venous occlusion plethysmography was conducted. RESULTS: The dose of acetylcholine at 50% maximal observed response (EC50) for black subjects was 10.6+/-2.39 microg/min and 3.3+/-0.44 microg/min in the white subjects (mean +/- SEM; P < .05). Sodium nitroprusside infusions at 1 and 2 microg/min did not cause a significant difference in response between the 2 groups. After angiotensin II was infused, forearm vascular resistance Emax was 3.42+/-0.78 mm Hg/100 mL tissue volume/min for black subjects and 3.16+/-0.99 mm Hg/100 mL tissue volume/min for white subjects. CONCLUSION: This study shows impaired endothelial-dependent forearm vascular relaxation as measured by decreased acetylcholine response in black subjects. This impairment in endothelial function may contribute to the increased incidence of hypertension in black subjects compared with white subjects. Mechanisms for this finding warrant further investigation.
Authors:
D S Jones; N S Andrawis; D R Abernethy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  65     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  408-12     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Georgetown University Medical Center, Washington, DC, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Adult
African Continental Ancestry Group*
Endothelium, Vascular / drug effects,  physiopathology*
European Continental Ancestry Group
Female
Forearm / blood supply*
Humans
Male
Nitroprusside / pharmacology
Plethysmography
Vasodilation* / drug effects
Vasodilator Agents / pharmacology*
Grant Support
ID/Acronym/Agency:
AG-08226/AG/NIA NIH HHS; GM 08386/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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