| Impaired elastic properties of ascending aorta in patients with giant cell arteritis. | |
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MedLine Citation:
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PMID: 15231510 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the elastic properties of the ascending aorta in untreated patients with giant cell arteritis compared with age and sex matched normal controls. METHODS: Distensibility of the ascending aorta and aortic strain were measured in 22 patients with a recent diagnosis of giant cell arteritis (documented by a positive temporal artery biopsy) before initiation corticosteroid treatment, and in 44 age and sex matched healthy subjects. Aortic distensibility was calculated as 2x[pulsatile change in aortic diameter]/[(diastolic aortic diameter)x(aortic pulse pressure)], and aortic strain as [pulsatile change in aortic diameter]/[diastolic aortic diameter]. Aortic diameters were measured by echocardiography. Aortic pressures were obtained by external sphygmomanometry. RESULTS: Distensibility of the ascending aorta and aortic strain were both lower in patients with giant cell arteritis than in the controls (p<0.01). In the patients with giant cell arteritis, aortic distensibility was inversely correlated with white blood cell count (p<0.05), but not with erythrocyte sedimentation rate or C reactive protein. CONCLUSIONS: Compared with healthy subjects, aortic distensibility and aortic strain are decreased in patients with giant cell arteritis before initiation of corticosteroid treatment. There was an association between the degree of reduction of aortic distensibility and the white blood cell count in the patient group. |
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Authors:
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P N Margos; I E Moyssakis; A G Tzioufas; E Zintzaras; H M Moutsopoulos |
Publication Detail:
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Type: Journal Article Date: 2004-07-01 |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 64 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-13 Completed Date: 2005-02-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 253-6 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, Medical School, National University of Athens, 75 M Asias Street, Goudi, 11527 Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aorta / physiopathology*, ultrasonography Echocardiography, Doppler Elasticity Female Giant Cell Arteritis / blood, physiopathology*, ultrasonography Humans Inflammation Mediators / blood Leukocyte Count Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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