| Impaired deoxyribonuclease I activity in patients with inflammatory bowel diseases. | |
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MedLine Citation:
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PMID: 21687600 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Background and Aims. Deoxyribonuclease I (DNaseI) is an endonuclease that facilitates chromatin breakdown and promotes susceptibility to autoimmune disorders. The aim of current study was to investigate serum DNase I activity in patients with inflammatory bowel diseases (IBD). Patients and Methods. A cohort of 110 IBD patients was evaluated, aged 35 ± 12 years, 77 with Crohn's disease (CD) and 33 with ulcerative colitis (UC). 50 SLE patients and 50 healthy blood donors were examined as control groups. Results. DNase I activity in IBD patients was significantly lower than in healthy individuals, but higher than in SLE patients (P < .0001). Patients with UC showed higher DNase I activity than CD patients, P = .21. DNase I activity in female patients with IBD was significantly lower than in males, P = .024; however, no differences in DNase I activity were found in relation to gender in healthy individuals. DNase I activity has shown a strong negative correlation with the serum concentration of anti-nucleosomal antibodies in the autoimmune (SLE + IBD) cohort, as well as in the separate IBD cohort. Conclusions. Reduced serum DNase I activity probably has pathogenetic consequences in IBD. Induction of autoantibodies towards nucleosomes could be a reflection of impaired DNase I activity. |
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Authors:
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Karin Malíčková; Dana Duricová; Martin Bortlík; Zdenka Hrušková; Barbora Svobodová; Naděžda Machková; Viktor Komárek; Terezie Fučíková; Ivana Janatková; Tomáš Zima; Milan Lukáš |
Publication Detail:
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Type: Journal Article Date: 2011-05-29 |
Journal Detail:
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Title: Autoimmune diseases Volume: 2011 ISSN: 2090-0430 ISO Abbreviation: Autoimmune Dis Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-20 Completed Date: 2011-07-14 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 101546750 Medline TA: Autoimmune Dis Country: England |
Other Details:
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Languages: eng Pagination: 945861 Citation Subset: - |
Affiliation:
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Institute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague, First Faculty of Medicine, Charles University in Prague, Karlovo nam. 32, 121 11 Prague 2, Czech Republic. |
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