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Impaired deoxyribonuclease I activity in patients with inflammatory bowel diseases.
MedLine Citation:
PMID:  21687600     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Background and Aims. Deoxyribonuclease I (DNaseI) is an endonuclease that facilitates chromatin breakdown and promotes susceptibility to autoimmune disorders. The aim of current study was to investigate serum DNase I activity in patients with inflammatory bowel diseases (IBD). Patients and Methods. A cohort of 110 IBD patients was evaluated, aged 35 ± 12 years, 77 with Crohn's disease (CD) and 33 with ulcerative colitis (UC). 50 SLE patients and 50 healthy blood donors were examined as control groups. Results. DNase I activity in IBD patients was significantly lower than in healthy individuals, but higher than in SLE patients (P < .0001). Patients with UC showed higher DNase I activity than CD patients, P = .21. DNase I activity in female patients with IBD was significantly lower than in males, P = .024; however, no differences in DNase I activity were found in relation to gender in healthy individuals. DNase I activity has shown a strong negative correlation with the serum concentration of anti-nucleosomal antibodies in the autoimmune (SLE + IBD) cohort, as well as in the separate IBD cohort. Conclusions. Reduced serum DNase I activity probably has pathogenetic consequences in IBD. Induction of autoantibodies towards nucleosomes could be a reflection of impaired DNase I activity.
Authors:
Karin Malíčková; Dana Duricová; Martin Bortlík; Zdenka Hrušková; Barbora Svobodová; Naděžda Machková; Viktor Komárek; Terezie Fučíková; Ivana Janatková; Tomáš Zima; Milan Lukáš
Publication Detail:
Type:  Journal Article     Date:  2011-05-29
Journal Detail:
Title:  Autoimmune diseases     Volume:  2011     ISSN:  2090-0430     ISO Abbreviation:  Autoimmune Dis     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-20     Completed Date:  2011-07-14     Revised Date:  2011-08-01    
Medline Journal Info:
Nlm Unique ID:  101546750     Medline TA:  Autoimmune Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  945861     Citation Subset:  -    
Affiliation:
Institute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague, First Faculty of Medicine, Charles University in Prague, Karlovo nam. 32, 121 11 Prague 2, Czech Republic.
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