Document Detail


Impaired delayed type cutaneous hypersensitivity in rheumatoid arthritis reversed by chrysotherapy.
MedLine Citation:
PMID:  2494956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prospective 24 week study of 31 patients with active rheumatoid arthritis (18 women, 13 men) was undertaken to determine whether weekly intramuscular sodium aurothiomalate (gold) would influence delayed type cutaneous hypersensitivity (DTH) and other indices of cell mediated immunity. DTH to seven recall antigens was measured by Multitest on three occasions during the study. Twenty five patients completed the study. At entry 13 patients (12 female) were anergic, and no significant correlations were found between DTH and other clinical and immunological indices. Women showed a significantly greater depression of DTH than men. At week 24 only three of the patients were anergic with significant increase in mean DTH score being noted particularly to tuberculin, candida, and streptococcus. Improvement in DTH was observed in both gold responders and non-responders. In conclusion, patients with active rheumatoid arthritis show impairment of DTH, which is reversed by chrysotherapy. This effect is most apparent in women and appears to be relatively independent of the clinical response.
Authors:
M D Smith; A Smith; J O'Donnell; M J Ahern; P J Roberts-Thomson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  48     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-04-24     Completed Date:  1989-04-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  108-13     Citation Subset:  IM    
Affiliation:
Department of Clinical Immunology, Flinders Medical Centre, Bedford Park, South Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Arthritis, Rheumatoid / drug therapy,  immunology*
Female
Gold Sodium Thiomalate / therapeutic use*
Humans
Hypersensitivity, Delayed / immunology*
Immunity, Cellular / drug effects
Male
Middle Aged
Prospective Studies
Sex Factors
Skin Tests
Chemical
Reg. No./Substance:
12244-57-4/Gold Sodium Thiomalate
Comments/Corrections

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