| Impaired counter-regulation of interleukin-1 by the soluble IL-1 receptor type II in patients with chronic liver disease. | |
| | |
MedLine Citation:
|
PMID: 18609176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the production of the endogenous IL-1 modulators IL-1 receptor antagonist (IL-1Ra), type I and II soluble IL-1 receptors (IL-1sRI and II) in patients with chronic liver disease (CLD). MATERIAL AND METHODS: Plasma levels of IL-1beta (IL-1beta) and IL-1 modulators were assessed in 126 CLD patients and 39 healthy controls. IL-1sRII was also measured in the supernatants of primary hepatocyte cultures. RESULTS: Plasma IL-1sRI and IL-1Ra levels were significantly higher in cirrhotic CLD patients than in non-cirrhotic CLD patients and in controls. Levels did not depend on the etiology of CLD. Likewise, plasma IL-1beta levels were elevated in CLD patients compared with those in controls. In contrast, IL-1sRII levels did not differ between CLD patients and controls. Cultures of human primary hepatocytes showed that IL-1sRII is induced by IL-1beta, but not IL-6. CONCLUSIONS: In cirrhotic CLD patients elevated plasma IL-1beta is not counteracted by endogenous levels of IL-1sRII, whereas high IL-1sRI is expected to neutralize the naturally occurring antagonist IL-1Ra, resulting in a dysregulation of the IL-1 system that might enhance pro-inflammatory activity of IL-1. |
| | |
Authors:
|
Othmar Ludwiczek; Edouard Vannier; Alexander Moschen; Adriana Salazar-Montes; Ingo Borggraefe; Cem Gabay; Barbara Enrich; Arthur Kaser; Britta Siegmund; Charles Dinarello; Herbert Tilg |
Related Documents
:
|
21063486 - Serum hs-crp was correlated with treatment response to pegylated interferon and ribavir... 19793666 - Spontaneous onset of complex regional pain syndrome. 20722986 - Association of maternal serum high sensitive c-reactive protein level with body mass in... 19351576 - Serum levels of c-reactive protein in patients with stable coronary artery disease: jup... 3877666 - Comparison of the oral (paba) pancreatic function test, the secretin-pancreozymin test ... 21057696 - High incidence of ankle arthropathy in mild and moderate haemophilia a. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 43 ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-10-22 Completed Date: 2009-02-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
|
Languages: eng Pagination: 1360-5 Citation Subset: IM |
Affiliation:
|
Academic Teaching Hospital Hall in Tyrol, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Case-Control Studies Chronic Disease Female Humans Interleukin-1beta / blood, metabolism* Liver Cirrhosis / metabolism Liver Diseases / metabolism* Male Middle Aged Receptors, Interleukin-1 Type I / biosynthesis*, blood Receptors, Interleukin-1 Type II / biosynthesis*, blood |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-1beta; 0/Receptors, Interleukin-1 Type I; 0/Receptors, Interleukin-1 Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum adipokine levels in chronic liver diseases: association of resistin levels with fibrosis sever...
Next Document: Role of earlier gastroscopy in predicting findings on repeat gastroscopy in a population with a low ...