Document Detail


Impaired coronary microvascular and left ventricular diastolic function in patients with inflammatory bowel disease.
MedLine Citation:
PMID:  25128749     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND AIM: Increased incidence of coronary vascular events in patients with inflammatory bowel disease (IBD) is known. However, the association between coronary microvascular function and IBD has not been fully defined. We aimed to investigate whether coronary flow reserve (CFR) and left ventricular diastolic function were impaired in IBD patients.
METHODS: Seventy-two patients with IBD (36 patients with ulcerative colitis [UC] and 36 Crohn's disease [CD]) were registered. Each subject was evaluated after a minimum 15-day attack-free period. For the control group, 36 age- and sex-matched healthy volunteers were included into the study. IBD clinical disease activity in UC was assessed by the Truelove-Witts Index (TWAS) and in CD by the Crohn's Disease Activity Index (CDAI). In each subject, CFR was measured through transthoracic Doppler echocardiography.
RESULTS: Compared to the controls, the CD group and UC group had significantly higher high-sensitivity C-reactive protein (hs-CRP) and erythrocyte sedimentation rate. Baseline diastolic peak flow velocity (DPFV) of the left anterior descending artery (LAD) was significantly higher in the IBD group (24.1±3.9 vs. 22. 4±2.9, p<0.05), and hyperemic DPFV (56.1±12.5 vs. 70.6±15.3, p<0.05) and CFR (2.34±0.44 vs. 3.14±0.54, p<0.05) were significantly lower in the IBD group than in the control group. In stepwise linear regression analysis, hs-CRP and lateral Em/Am ratio were independently correlated with CFR.
CONCLUSION: CFR, reflecting coronary microvascular function, is impaired in patients with IBD. CFR and left ventricular diastolic function parameters are well correlated with hs-CRP.
Authors:
Zuhal Caliskan; Huseyin Savas Gokturk; Mustafa Caliskan; Hakan Gullu; Ozgur Ciftci; Gülsüm Teke Ozgur; Aytekin Guven; Haldun Selcuk
Related Documents :
6829429 - Electrocardiographic criteria for the diagnosis of combined inferior myocardial infarct...
23685299 - Impact of ad hoc percutaneous coronary intervention with drug-eluting stents in angina ...
16865219 - Electrocardiographical case. a man found unconscious.
14655239 - Additional electrocardiographic leads in the ed chest pain patient: right ventricular a...
1823009 - The electrocardiogram of rats with an old extensive myocardial infarction.
2975319 - False-positive posterior myocardial infarct criteria during left anterior descending co...
19121429 - Usefulness of three posterior chest leads for the detection of posterior wall acute myo...
1510509 - Composite valve graft replacement of the proximal aorta: comparison of techniques in 34...
24762249 - Using galectin-3 to reduce heart failure rehospitalization.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-13
Journal Detail:
Title:  Microvascular research     Volume:  -     ISSN:  1095-9319     ISO Abbreviation:  Microvasc. Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of intracerebroventricular injections of 5-HT on systemic vascular resistances of conscious ...
Next Document:  Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascula...