Document Detail


Impaired contractility of left-over vein grafts used for CABG and the possible trauma caused by air exposure.
MedLine Citation:
PMID:  11837520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The patency of vein grafts limits the long-term results after bypass surgery. Vein graft trauma may contribute to the clinical results. DESIGN: Left-over pieces of vein after routine coronary bypass surgery were compared with references of the same vein that were stored with maximum care. Blood perfusion (20 h, 37 degrees C) was also tested to evaluate possible recovery. Vessel rings were measured by isometric tone recordings. RESULTS: Left-over veins showed a contractile dysfunction compared to reference (p < 0.01-0.001, n = 13), and that did not recover after blood perfusion. Four trauma models were tested, using saphenous vein graft (SVG)-references (n = 5). Chemical exposures (0-90 min) to NaCl-papaverin or cardioplegic medium affected the baseline (p < 0.05-0.01). With mechanical distension, up to 450 mmHg leak testing, an increased norepinephrine (NE) reactivity appeared. Air contact, 20 min, reduced the NE reactivity to half maximum (p < 0.05). Longer exposures (40-60 min) completely abolished the contractility. CONCLUSIONS: The saphenous vein smooth muscle function appeared permanently traumatized following routine harvesting and handling. Air exposure gave dramatic deterioration and could in theory contribute to hamper the long-term results after bypass surgery.
Authors:
K G Engström; I Szentkiralyi
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  35     ISSN:  1401-7431     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-02-11     Completed Date:  2002-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  403-8     Citation Subset:  IM    
Affiliation:
Department of Surgery and Perioperative Science, Caidiothoracic Division, Umeå University Hospital, Sweden. Gunnar.Engstrom.us@vll.se
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Artery Bypass*
Female
Humans
Male
Middle Aged
Muscle, Smooth, Vascular / physiopathology*
Postoperative Period
Saphenous Vein / physiopathology,  transplantation*
Tissue and Organ Harvesting / adverse effects*
Vascular Patency
Vasomotor System / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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