| Impaired comprehension of temporal connectives in Parkinson's disease - a neuroimaging study. | |
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MedLine Citation:
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PMID: 22561179 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Parkinson's disease has been found to impair comprehension of complex sentences. Here we follow up on earlier findings that sentences describing two successive events in the form of "Before B, A" are understood worse by Parkinson patients than sentences in the form of "After A, B". Before-initial sentences express events in an order inconsistent with their actual order of occurrence and therefore require additional computations during comprehension. In a behavioral study we tested whether 28 German Parkinson patients reading 'before' and 'after'-initial sentences correctly understood the sequence of events. A second functional magnetic resonance imaging study investigated 16 different patients who read sentences while in the scanner. The behavioral study revealed that 'before' sentences were misunderstood with regard to the temporal sequence of events in 53% (controls 6.5%). The imaging study demonstrated a functional network of the caudate nucleus, middle frontal gyrus, medial superior frontal gyrus, parietal lobule and inferior temporal gyrus. This network was dynamically modulated for 'before' than 'after' sentences in healthy controls but not in Parkinson patients. The current results suggest that the additional computations required for 'before' sentences are supported by a network with the caudate nucleus as a central element. This network was compromised in Parkinson patients. We propose that dysfunction of the caudate nucleus networks underlies Parkinson patients' difficulty in dealing with complex sentence structures. |
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Authors:
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Zheng Ye; Maria Milenkova; Bahram Mohammadi; Katja Kollewe; Christoph Schrader; Reinhard Dengler; Amir Samii; Thomas F Münte |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-3 |
Journal Detail:
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Title: Neuropsychologia Volume: - ISSN: 1873-3514 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0020713 Medline TA: Neuropsychologia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurology, University of Lübeck, Lübeck, Germany; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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