Document Detail

Impaired chemosensitivity and perception of dyspnoea in Parkinson's disease.
MedLine Citation:
PMID:  11085699     Owner:  NLM     Status:  MEDLINE    
Exacerbation of respiratory failure in Parkinson's disease could be the result of impaired perception of hypoxia. We assessed chemosensitivity to hypoxia and hypercapnia and perception of dyspnoea on the Borg scale in 25 patients (Hoehn and Yahr stage 2-3) and 11 controls. Chemosensitivity to hypoxia, but not that in response to hypercapnia, was lower in patients than in controls (0.196 [SE 0.030] vs 0.525 [0.360]; p=0.012); the mean Borg score was lower in patients than in controls under hypoxic conditions (2.9 [SD 1.4] vs 4.8 [2.1]; p=0.0015). Thus, even at an early stage of disease, patients with Parkinson's disease had a subnormal hypoxic response accompanied by blunted perception of dyspnoea.
H Onodera; S Okabe; Y Kikuchi; T Tsuda; Y Itoyama
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Lancet     Volume:  356     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-11-30     Completed Date:  2000-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  739-40     Citation Subset:  AIM; IM    
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MeSH Terms
Anoxia / complications*
Case-Control Studies
Dyspnea / complications*
Hypercapnia / complications*
Linear Models
Middle Aged
Parkinson Disease / complications,  physiopathology*
Respiratory Function Tests
Comment In:
Lancet. 2000 Dec 16;356(9247):2100   [PMID:  11145519 ]
Lancet. 2000 Dec 16;356(9247):2099   [PMID:  11145518 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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