Document Detail

Impaired catecholamine inactivation. A prohypertensive stimulus after dietary linoleate deficiency in salt-loaded rats?
MedLine Citation:
PMID:  6581124     Owner:  NLM     Status:  MEDLINE    
Experiments were carried out on salt-loaded rats (1.5% NaCl as drinking fluid) to further explore the mechanisms by which blood pressure increases after a linoleic acid-deficient (LAd) diet. In 4-week-old LAd rats (0.5 cal% LA, hydrogenated palm kernel fat) compared to linoleic acid-rich rats (LAr, 13.3 cal% LA, sunflower oil), we observed, from the base of a reduced content of omega-6-polyunsaturated fatty acids in the tissues, an increase in blood pressure by 12 mm Hg (p less than 0.001), a diminished formation of prostaglandin E (PGE), and an unchanged formation of PGF in the aorta as well as a reduction in the in vitro uptake of 14C-norepinephrine into cardiac, aortic, and renal tissues, and a reduced degradation rate of 14C-norepinephrine in cardiac tissue. These differences in LAr vs LAd rats were not exaggerated. With respect to aortic PGE formation, 14C-norepinephrine uptake into aortic and renal tissues and 14C-norepinephrine degradation even lessened when the diet was begun prenatally, although the reduction of omega 6-polyunsaturated fatty acids in the tissues was aggravated. Our conclusion is that a fault in catecholamine inactivation may be involved in the pathogenesis of increased sympathetic activity and blood pressure elevation in LAd-fed, salt-loaded rats, possibly via alterations of endogenous prostanoid formation.
P Hoffmann; C Taube; J Beitz; W Förster; W S Poleshuk; C M Markov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  5     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1983 Nov-Dec
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  968-75     Citation Subset:  IM    
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MeSH Terms
Aorta / metabolism
Blood Pressure
Body Weight
Carbon Radioisotopes
Fatty Acids, Unsaturated / metabolism
Hypertension / etiology*
Kidney / metabolism
Linoleic Acid
Linoleic Acids / deficiency*
Myocardium / metabolism
Norepinephrine / metabolism*
Prostaglandins E / biosynthesis
Prostaglandins F / biosynthesis
Rats, Inbred Strains
Sodium Chloride / administration & dosage
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 0/Prostaglandins E; 0/Prostaglandins F; 2197-37-7/Linoleic Acid; 363-24-6/Dinoprostone; 51-41-2/Norepinephrine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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