| Impaired brain growth and neurodevelopment in preterm infants with post-hemorrhagic ventricular dilatation. | |
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MedLine Citation:
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PMID: 22452585 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim To correlate volumetric magnetic resonance imaging at term with neurodevelopmental outcome at 2 years in infants with post-hemorrhagic ventricular dilatation. Preterm infants with post-hemorrhagic ventricular dilatation have high risk of disabilities but the range is wide and predicting severity of motor and mental disability is difficult. Methods 25 preterm infants with post-hemorrhagic ventricular dilatation had cerebral magnetic resonance imaging at term age. Total and regional brain volumes were calculated using a manual segmentation technique. Bayley Scales of Infant Development II were assessed at 2 years post term. Developmental Quotients (DQ) were calculated from Developmental Age Equivalent scores. Results Total cerebral volume, excluding ventricles, correlated positively with Motor (r = 0.8, p<0.0001), and Mental DQ (r =0.4,p=0.02). Only 3 out of 16 infants with cerebral volume <336 cm(3) were ambulant at 2 years. Cerebellar volumes correlated strongly with Motor DQ (r=0.6,p=0.002) but only with Mental DQ after adjustment. Thalamic volumes correlated strongly with Motor DQ (r=0.7,p=0.0002). Conclusion Brain growth is significantly impaired in post-hemorrhagic ventricular dilatation. Volumetric measurements at term of total cerebral and cerebellar volume may have a role in predicting severity of disability. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. |
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Authors:
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Sally Jary; Agnese De Carli; Luca A Ramenghi; Andrew Whitelaw |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-27 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica. |
Affiliation:
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School of Clinical Science, University of Bristol, Southmead Hospital, Bristol, United Kingdom. NICU, University Department of Mother and Infant Sciences, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Neonatal Intensive Care Unit, Giannina Gaslini Paediatric Institute, Genoa, Italy. |
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