Document Detail

Impaired blood pressure recovery to hemorrhage in obese Zucker rats with orthopedic trauma.
MedLine Citation:
PMID:  22003055     Owner:  NLM     Status:  MEDLINE    
We have shown that obese Zucker rats with orthopedic trauma (OZT) exhibit a loss of arteriolar tone in skeletal muscle. We hypothesize that the loss of arteriolar tone in OZT blunts vasoconstrictor responses to hemorrhage, resulting in an impaired blood pressure recovery. Orthopedic trauma was induced with soft tissue injury and local injection of bone components in both hindlimbs in lean (LZT) and OZT (11-13 wk). One day after the orthopedic trauma, blood pressure responses following hemorrhage were measured in conscious control lean, control obese, LZT, and OZT. In another set of experiments, the spinotrapezius muscle of control and trauma animals was prepared for microcirculatory observation. Arteriolar responses to phenylephrine (PE) or hemorrhage were determined. Hemorrhage resulted in similar blood pressure responses in control animals and LZT, but the blood pressure recovery following hemorrhage was blunted in the OZT. In the spinotrapezius, OZT exhibited decreased arteriolar tone and blunted vasoconstrictor responses to PE and hemorrhage. Treatment with glibenclamide improved the blood pressure recovery in the conscious OZT and improved the arteriolar tone, and PE induced vasoconstriction in the spinotrapezius of the OZT. Thus, ATP-dependent K(+) channel-mediated loss of arteriolar tone in OZT blunts the arteriolar constriction to hemorrhage, resulting in impaired blood pressure recovery.
Lusha Xiang; Silu Lu; William Fuller; Arun Aneja; George V Russell; Louis B Jones; Robert Hester
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-14
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  302     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-27     Completed Date:  2012-02-14     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H340-8     Citation Subset:  IM    
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MeSH Terms
Arterioles / physiopathology
Blood Pressure* / drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Femoral Fractures / complications*,  physiopathology
Glyburide / pharmacology
Heart Rate
Hemorrhage / complications,  metabolism,  physiopathology*
KATP Channels / antagonists & inhibitors,  metabolism
Muscle, Skeletal / blood supply*
Obesity / complications*,  physiopathology
Phenylephrine / pharmacology
Potassium Channel Blockers / pharmacology
Rats, Zucker
Recovery of Function
Soft Tissue Injuries / complications*,  physiopathology
Time Factors
Vasoconstrictor Agents / pharmacology
Grant Support
Reg. No./Substance:
0/KATP Channels; 0/Potassium Channel Blockers; 0/Vasoconstrictor Agents; 1WS297W6MV/Phenylephrine; SX6K58TVWC/Glyburide

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