| Impaired blood pressure recovery to hemorrhage in obese Zucker rats with orthopedic trauma. | |
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MedLine Citation:
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PMID: 22003055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have shown that obese Zucker rats with orthopedic trauma (OZT) exhibit a loss of arteriolar tone in skeletal muscle. We hypothesize that the loss of arteriolar tone in OZT blunts vasoconstrictor responses to hemorrhage, resulting in an impaired blood pressure recovery. Orthopedic trauma was induced with soft tissue injury and local injection of bone components in both hindlimbs in lean (LZT) and OZT (11-13 wk). One day after the orthopedic trauma, blood pressure responses following hemorrhage were measured in conscious control lean, control obese, LZT, and OZT. In another set of experiments, the spinotrapezius muscle of control and trauma animals was prepared for microcirculatory observation. Arteriolar responses to phenylephrine (PE) or hemorrhage were determined. Hemorrhage resulted in similar blood pressure responses in control animals and LZT, but the blood pressure recovery following hemorrhage was blunted in the OZT. In the spinotrapezius, OZT exhibited decreased arteriolar tone and blunted vasoconstrictor responses to PE and hemorrhage. Treatment with glibenclamide improved the blood pressure recovery in the conscious OZT and improved the arteriolar tone, and PE induced vasoconstriction in the spinotrapezius of the OZT. Thus, ATP-dependent K(+) channel-mediated loss of arteriolar tone in OZT blunts the arteriolar constriction to hemorrhage, resulting in impaired blood pressure recovery. |
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Authors:
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Lusha Xiang; Silu Lu; William Fuller; Arun Aneja; George V Russell; Louis B Jones; Robert Hester |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-10-14 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 302 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-27 Completed Date: 2012-02-14 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H340-8 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, 39216-4505, USA. Lxiang2@umc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / physiopathology Blood Pressure* / drug effects Disease Models, Animal Dose-Response Relationship, Drug Femoral Fractures / complications*, physiopathology Glyburide / pharmacology Heart Rate Hemorrhage / complications, metabolism, physiopathology* KATP Channels / antagonists & inhibitors, metabolism Male Microcirculation Muscle, Skeletal / blood supply* Obesity / complications*, physiopathology Phenylephrine / pharmacology Potassium Channel Blockers / pharmacology Rats Rats, Zucker Recovery of Function Soft Tissue Injuries / complications*, physiopathology Time Factors Vasoconstriction Vasoconstrictor Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL-51971/HL/NHLBI NIH HHS; HL-89581/HL/NHLBI NIH HHS; R01 HL089581-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/KATP Channels; 0/Potassium Channel Blockers; 0/Vasoconstrictor Agents; 10238-21-8/Glyburide; 59-42-7/Phenylephrine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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