Document Detail


Impaired blood pressure compensation following hemorrhage in conscious obese Zucker rats.
MedLine Citation:
PMID:  23782999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Hemorrhagic shock leads to a higher risk of mortality and morbidity in obese patients, however the mechanisms for these outcomes are unclear. We hypothesized that following severe hemorrhage, blood pressure control in conscious obese Zucker rats (OZ) is impaired.
MAIN METHODS: Experiments were performed in conscious lean Zucker rats (LZ) and OZ. Blood pressure, heart rate, cardiac output, total peripheral resistance (TPR), plasma renin activity (PRA), plasma antidiuretic hormone (ADH), and blood gasses were measured before and after severe hemorrhage (35% of the total blood volume).
KEY FINDINGS: Basal blood pressure, cardiac output, TPR, PRA, and ADH levels were not different between LZ and OZ. Compared to LZ, OZ exhibited impaired baroreflex control of heart rate and showed higher levels of vascular adrenergic tone. One hour after the hemorrhage, LZ and OZ exhibited similar decreases in cardiac output. However, blood pressure, heart rate, TPR, PRA, and ADH levels were lower in OZ than in LZ.
SIGNIFICANCE: These results indicate that conscious OZ has impaired blood pressure compensation after hemorrhage due to a blunted increase in TPR. This is due at least in part to an impaired regulation of vasoconstrictor hormones. To our knowledge, the current study is the first to demonstrate that hemodynamic responses and associated hormone secretion are impaired in a conscious obese model.
Authors:
Lusha Xiang; John S Clemmer; Silu Lu; Peter N Mittwede
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-06-16
Journal Detail:
Title:  Life sciences     Volume:  93     ISSN:  1879-0631     ISO Abbreviation:  Life Sci.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-29     Completed Date:  2013-10-22     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  214-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Baroreflex / genetics
Blood Pressure / genetics*
Consciousness / physiology*
Heart Rate / genetics
Hemodynamics / genetics*
Hemorrhage / complications,  genetics,  physiopathology*
Male
Obesity / genetics,  physiopathology*
Rats
Rats, Zucker
Grant Support
ID/Acronym/Agency:
HL-51971/HL/NHLBI NIH HHS; HL-89581/HL/NHLBI NIH HHS; P01 HL051971/HL/NHLBI NIH HHS; R01 HL089581/HL/NHLBI NIH HHS; T32 HL-105324/HL/NHLBI NIH HHS; T32 HL105324/HL/NHLBI NIH HHS
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