Document Detail


Impaired beta-adrenoceptor function, increased leukocyte respiratory burst, and bronchial hyperresponsiveness.
MedLine Citation:
PMID:  1331219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammatory processes have potential importance in the pathogenesis of bronchial hyperresponsiveness and asthma. Because beta-adrenoceptor function may be impaired in asthma, we studied regulation of the leukocyte respiratory burst using blood samples from subjects with bronchial hyperresponsiveness to methacholine. Leukocytes from hyperresponsive subjects were less responsive to the beta-agonist isoproterenol than were leukocytes from healthy control subjects. The magnitude of the respiratory burst was increased in cells from hyperresponsive subjects and correlated with the degree of methacholine responsiveness. These results demonstrate that peripheral leukocytes reflect a functional impairment in beta-adrenergic responsiveness that parallels airway hyperresponsiveness. Because untreated subjects demonstrated a reduction in beta-adrenergic response, the impairment in beta-adrenoceptor function was not a result of drug therapy and may be associated with the pathogenesis of asthma.
Authors:
C P Nielson; J J Crowley; R E Vestal; M J Connolly
Related Documents :
6140229 - Effects of acute beta-adrenergic blockade on blood and muscle lactate concentration dur...
2897299 - Reduction of exercise tachycardia in man after propranolol, atenolol and bisoprolol in ...
1687999 - Cardiac beta 2-adrenoceptors and the inotropic response to exercise in man.
22228269 - Exercise and amyotrophic lateral sclerosis.
41449 - Inefficacy of digitalis in the control of heart rate in patients with chronic atrial fi...
12562839 - Single session exercise stimulates formation of pre beta 1-hdl in leg muscle.
17086769 - Cns oxygen toxicity in closed-circuit diving: signs and symptoms before loss of conscio...
19088769 - High-intensity aerobic interval training increases fat and carbohydrate metabolic capac...
24314679 - Exercise in multiple sclerosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  90     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-22     Completed Date:  1992-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  825-32     Citation Subset:  AIM; IM    
Affiliation:
Clinical Pharmacology and Gerontology Research Unit, Department of Veterans Affairs Medical Center, Boise, ID 83702.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asthma / physiopathology
Bronchial Hyperreactivity / physiopathology*
Humans
Leukocytes / metabolism*
Middle Aged
Receptors, Adrenergic, beta / physiology*
Respiratory Burst*
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Platelet-activating factor enhances interleukin-6 production by alveolar macrophages.
Next Document:  Bovine inositol monophosphatase: development of a continuous fluorescence assay of enzyme activity.