| Impaired basal thermal homeostasis in rats lacking capsaicin-sensitive peripheral small sensory neurons. | |
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MedLine Citation:
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PMID: 18079164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effects of selective loss of capsaicin-sensitive primary sensory neurons on thermosensation and thermoregulation in rats. Neonatal capsaicin treatment in rats caused a remarkable decrease in the number of small-diameter neurons in the dorsal root ganglion (DRG) compared with their number in the control rats. Gene expression analysis for various thermo-sensitive transient receptor potential (TRP) channels indicated marked reductions in the mRNA levels of TRPV1 (70%), TRPM8 (46%) and TRPA1 (64%), but not of TRPV2, in the DRG of capsaicin-treated rats compared with those in the control rats. In addition to the heat and cold insensitivity, capsaicin-treated rats showed lower rectal core temperature, higher skin temperature and decreased sensitivity to ambient temperature alteration under normal housing at room temperature, suggesting impaired thermosensation and change in thermoregulation in the rats. Uncoupling protein 1 (UCP1) expression and the thermogenic ability in brown adipose tissues were attenuated in the capsaicin-treated rats. These results indicate a critical role of capsaicin-sensitive sensory neurons in both heat and cool sensation and hence in basal thermal homeostasis, which is balanced by heat release and production including UCP1 thermogenesis, following sensation of the ambient temperature. |
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Authors:
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Hitoshi Yamashita; Zuocheng Wang; Youxue Wang; Tatsuo Furuyama; Yasuhide Kontani; Yuzo Sato; Nozomu Mori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-13 |
Journal Detail:
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Title: Journal of biochemistry Volume: 143 ISSN: 0021-924X ISO Abbreviation: J. Biochem. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2008-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376600 Medline TA: J Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 385-93 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan. hyamashi@isc.chubu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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drug effects,
metabolism Animals Animals, Newborn Body Temperature Regulation / drug effects* Capsaicin / pharmacology* Female Ganglia, Spinal / cytology, drug effects Gene Expression Regulation / drug effects Ion Channels / metabolism Male Mitochondrial Proteins / metabolism Neurons, Afferent / drug effects*, physiology* RNA, Messenger / genetics, metabolism Rats Rats, Inbred F344 TRPM Cation Channels / genetics, metabolism TRPV Cation Channels / genetics, metabolism Temperature Sense / drug effects Thermogenesis / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 0/Mitochondrial Proteins; 0/RNA, Messenger; 0/TRPM Cation Channels; 0/TRPV Cation Channels; 0/mitochondrial uncoupling protein; 404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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